(2R)-2-Hydroxy-2,3,3-trimethylbutanoic acid

Base Information

• Chemical Name: (2R)-2-Hydroxy-2,3,3-trimethylbutanoic acid
• CAS No.: 1184-93-6
• Molecular Formula: C7H14O3
• Molecular Weight: 146.186
• DSSTox Substance ID: DTXSID60552676
• Nikkaji Number: J57.301I
• Wikidata: Q82433038
• Mol file: 1184-93-6.mol

Synonyms:(2R)-2-Hydroxy-2,3,3-trimethylbutanoic acid;1184-93-6;SCHEMBL2102481;DTXSID60552676;VPZUWGSCTZUBFG-ZETCQYMHSA-N;AKOS006380905;(R) -2,3,3-trimethyl-2-hydroxybutanoic acid

Chemical Property of (2R)-2-Hydroxy-2,3,3-trimethylbutanoic acid

Chemical Property:

• XLogP3: 1.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 146.094294304
• Heavy Atom Count: 10
• Complexity: 145

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)C(C)(C(=O)O)O
• Isomeric SMILES: C[C@](C(=O)O)(C(C)(C)C)O

Technology Process of (2R)-2-Hydroxy-2,3,3-trimethylbutanoic acid

There total 2 articles about (2R)-2-Hydroxy-2,3,3-trimethylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ (1,1-Dimethylethyl)carbamic acid, 3-[[3-[(2-hydroxy-2,3,3-trimethyl-1-oxobutyl)amino]-2-hydroxy-4-phenylbutyl]amino]-2-hydroxy-1-(phenylmethyl)propyl ester + (R)-(+)-2-hydroxy-2,3,3-trimethylbutanoic acid (1184-93-6)

Guidance literature:

Reference yield:

(R,S)-2-hydroxy-2,3,3-trimethylbutanoic acid (4026-21-5) + (R)-2-amino-3-phenylpropanol (5267-64-1) → (R)-(+)-2-hydroxy-2,3,3-trimethylbutanoic acid (1184-93-6) + (R)-2-Amino-3-phenyl-propan-1-ol; compound with (S)-2-hydroxy-2,3,3-trimethyl-butyric acid

Guidance literature:

In di-isopropyl ether; isopropyl alcohol; at 60 ℃; for 36h;

DOI:10.1002/ejoc.200390179

Reference yield: 89.0%

(R)-(+)-2-hydroxy-2,3,3-trimethylbutanoic acid (1184-93-6) + N-(Benzyloxycarbonyl)glycine (1138-80-3) → (R)-2-(N-benzyloxycarbonylaminoacetoxy)2,3,3-trimethylbutanoic acid (565237-50-5)

Guidance literature:

With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; for 20h;

DOI:10.1002/ejoc.200390179

upstream raw materials:

(R,S)-2-hydroxy-2,3,3-trimethylbutanoic acid

(R)-2-amino-3-phenylpropanol

Downstream raw materials:

(R)-2-(N-benzyloxycarbonylaminoacetoxy)2,3,3-trimethylbutanoic acid

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