N-cyclohexyl-6-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-amine

Base Information

• Chemical Name: N-cyclohexyl-6-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-amine
• CAS No.: 118498-97-8
• Molecular Formula: C19H26N2
• Molecular Weight: 282.42300
• DSSTox Substance ID: DTXSID20385609
• ChEMBL ID: CHEMBL3092073
• Mol file: 118498-97-8.mol

Synonyms:N-cyclohexyl-6-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-amine;ChemDiv3_004779;118498-97-8;Oprea1_466733;SCHEMBL4163723;CHEMBL3092073;DTXSID20385609;HMS1486J05;STL324826;AKOS001674253;IDI1_022689;AB00079481-01;BRD-A15711336-003-01-1

Chemical Property of N-cyclohexyl-6-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-amine

Chemical Property:

• PSA: 27.82000
• LogP: 5.16690
• XLogP3: 4.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 282.209598838
• Heavy Atom Count: 21
• Complexity: 350

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC2=C(C=C1)NC3=C2CCCC3NC4CCCCC4

Technology Process of N-cyclohexyl-6-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-amine

There total 4 articles about N-cyclohexyl-6-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.5%

6-Methyl-1-cyclohexylimino-1,2,3,4-tetrahydrocarbazole (118499-06-2) → 6-Methyl-1-cyclohexylamino-1,2,3,4-tetrahydrocarbazole (118498-97-8)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 20 ℃; for 1h;

DOI:10.1007/BF00763273

Reference yield:

6-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-one (3449-48-7,812649-03-9) → 6-Methyl-1-cyclohexylamino-1,2,3,4-tetrahydrocarbazole (118498-97-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / toluene / 7 h / Heating

2: 80.5 percent / NaBH₄ / ethanol / 1 h / 20 °C

With sodium tetrahydroborate; In ethanol; toluene;

DOI:10.1007/BF00763273

Reference yield:

cyclohexylamine (108-91-8,157973-60-9) → 6-Methyl-1-cyclohexylamino-1,2,3,4-tetrahydrocarbazole (118498-97-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / toluene / 7 h / Heating

2: 80.5 percent / NaBH₄ / ethanol / 1 h / 20 °C

With sodium tetrahydroborate; In ethanol; toluene;

DOI:10.1007/BF00763273

upstream raw materials:

6-Methyl-1-cyclohexylimino-1,2,3,4-tetrahydrocarbazole

6-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-one

cyclohexylamine

Refernces

• 1、 Filitis, L. N.,Akalaeva, T. V.,Amel'kin, O. Yu.,Bokanov, A. I.,Ivanov, P. Yu.,Shvedov, V. I.. "SYNTHESIS AND IN VITRO ANTITUBERCULAR ACTIVITY OF ALKYLAMINOTETRAHYDROCARBAZOLES". . p. 780 - 785. Retrieved 2007/10/02.