(2-heptyl-1-hydroxycyclohexyl)carbonitrile

Base Information

• Chemical Name: (2-heptyl-1-hydroxycyclohexyl)carbonitrile
• CAS No.: 73978-29-7
• Molecular Formula: C₁₄H₂₅NO
• Molecular Weight: 223.359
• Mol file: 73978-29-7.mol

Synonyms:

Chemical Property of (2-heptyl-1-hydroxycyclohexyl)carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-heptyl-1-hydroxycyclohexyl)carbonitrile

There total 1 articles about (2-heptyl-1-hydroxycyclohexyl)carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-heptylcyclohexanone (3313-59-5) + 2-hydroxy-2-methylpropanenitrile (75-86-5) → (2-heptyl-1-hydroxycyclohexyl)carbonitrile (73978-29-7)

Guidance literature:

With triethylamine; for 2h; Ambient temperature;

DOI:10.1002/jps.2600690221

Reference yield:

(2-heptyl-1-hydroxycyclohexyl)carbonitrile (73978-29-7) → 6-n-heptylcyclohex-1-enecarbonitrile (73978-31-1)

Guidance literature:

With pyridine; thionyl chloride; at 140 ℃; for 1h;

DOI:10.1002/jps.2600690221

Reference yield:

(2-heptyl-1-hydroxycyclohexyl)carbonitrile (73978-29-7) → methyl 6-heptyl-1-cyclohexene-1-carboxylate

Guidance literature:

Multi-step reaction with 3 steps

1: 1.6 g / thionyl chloride, pyridine / 1 h / 140 °C

2: 1.) H₂SO₄, 2.) sodium nitrite / 1) acetic acid, 110 deg C, 18 h; 2) water, acetic acid, room temperature (20 min), 80 deg C (1.5 h)

3: 95 percent / diethyl ether / 1) 0 deg C, 40 min; 2) room temperature, 30 min

With pyridine; thionyl chloride; sulfuric acid; sodium nitrite; In diethyl ether;

DOI:10.1002/jps.2600690221

upstream raw materials:

2-heptylcyclohexanone

2-hydroxy-2-methylpropanenitrile

Downstream raw materials:

(1-acetoxy-2-heptylcyclohexyl)carbonitrile

6-n-heptylcyclohex-1-enecarbonitrile

6-n-heptylcyclohex-1-enecarboxylic acid