Technology Process of methyl 3-amino-5-bromo-6-fluoro-2-methylbenzoate
There total 3 articles about methyl 3-amino-5-bromo-6-fluoro-2-methylbenzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sulfuric acid / 6 h / 20 °C / Inert atmosphere
2: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere
3: ammonium chloride; iron / water; methanol / 2.5 h / 70 °C
With
sulfuric acid; iron; potassium carbonate; ammonium chloride;
In
methanol; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: nitric acid; sulfuric acid / 0.75 h / -5 - 0 °C / Cooling with acetone-ice
2: sulfuric acid / 6 h / 20 °C / Inert atmosphere
3: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere
4: ammonium chloride; iron / water; methanol / 2.5 h / 70 °C
With
sulfuric acid; nitric acid; iron; potassium carbonate; ammonium chloride;
In
methanol; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere
2: ammonium chloride; iron / water; methanol / 2.5 h / 70 °C
With
iron; potassium carbonate; ammonium chloride;
In
methanol; water; N,N-dimethyl-formamide;
