N²-Isobutyryl-5'-O-monomethoxytrityl-2'-deoxyguanosine-3' 2,5-dichlorophenyl 2-(4-nitrophenyl)-ethyl phosphate

Base Information

• Chemical Name: N²-Isobutyryl-5'-O-monomethoxytrityl-2'-deoxyguanosine-3' 2,5-dichlorophenyl 2-(4-nitrophenyl)-ethyl phosphate
• CAS No.: 95990-96-8
• Molecular Formula: C₄₈H₄₅Cl₂N₆O₁₁P
• Molecular Weight: 983.799
• Mol file: 95990-96-8.mol

Synonyms:

Chemical Property of N²-Isobutyryl-5'-O-monomethoxytrityl-2'-deoxyguanosine-3' 2,5-dichlorophenyl 2-(4-nitrophenyl)-ethyl phosphate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N²-Isobutyryl-5'-O-monomethoxytrityl-2'-deoxyguanosine-3' 2,5-dichlorophenyl 2-(4-nitrophenyl)-ethyl phosphate

There total 5 articles about N²-Isobutyryl-5'-O-monomethoxytrityl-2'-deoxyguanosine-3' 2,5-dichlorophenyl 2-(4-nitrophenyl)-ethyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2'-Deoxyguanosine (961-07-9) → N2-Isobutyryl-5'-O-monomethoxytrityl-2'-deoxyguanosine-3' 2,5-dichlorophenyl 2-(4-nitrophenyl)-ethyl phosphate (95990-96-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 90 percent / pyridine / CHCl₃ / 2 h / Ambient temperature

2: 77 percent / aq. NaOH / ethanol / 0.25 h / 0 °C

3: 85 percent / pyridine / 6 h / Ambient temperature

4: 1.) 1,2,4-triazole, pyridine / 1.) 30 min, 2.) 6 h, room temp.

With pyridine; 1,2,4-Triazole; sodium hydroxide; In ethanol; chloroform;

DOI:10.1055/s-1984-31040

Reference yield:

2'-deoxy-N2-isobutyrylguanosine 3',5'-diisobutyrate (82921-42-4) → N2-Isobutyryl-5'-O-monomethoxytrityl-2'-deoxyguanosine-3' 2,5-dichlorophenyl 2-(4-nitrophenyl)-ethyl phosphate (95990-96-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 77 percent / aq. NaOH / ethanol / 0.25 h / 0 °C

2: 85 percent / pyridine / 6 h / Ambient temperature

3: 1.) 1,2,4-triazole, pyridine / 1.) 30 min, 2.) 6 h, room temp.

With pyridine; 1,2,4-Triazole; sodium hydroxide; In ethanol;

DOI:10.1055/s-1984-31040

Reference yield:

N-isobutyryl-2'-deoxyguanosine (68892-42-2) → N2-Isobutyryl-5'-O-monomethoxytrityl-2'-deoxyguanosine-3' 2,5-dichlorophenyl 2-(4-nitrophenyl)-ethyl phosphate (95990-96-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / pyridine / 6 h / Ambient temperature

2: 1.) 1,2,4-triazole, pyridine / 1.) 30 min, 2.) 6 h, room temp.

With pyridine; 1,2,4-Triazole;

DOI:10.1055/s-1984-31040

upstream raw materials:

2-(4-nitrophenyl)ethanol

2,5-dichlorophenyl phosphorodichloridate

N²-Isobutyryl-5'-O-monomethoxytrityl-2'-deoxyguanosine

N-isobutyryl-2'-deoxyguanosine