Mal-PEG1-NHS ester

Base Information

• Chemical Name: Mal-PEG1-NHS ester
• CAS No.: 1807518-72-4
• Molecular Formula: C₁₃H₁₄N₂O₇
• Molecular Weight: 310.263
• Mol file: 1807518-72-4.mol

Synonyms:

Chemical Property of Mal-PEG1-NHS ester

Chemical Property:

• Boiling Point: 488.4±55.0 °C(Predicted)
• PKA: -2.35±0.20(Predicted)
• Density: 1.48±0.1 g/cm3(Predicted)
• Solubility.: Soluble in DCM

Purity/Quality:

99%, ^*data from raw suppliers

Mal-PEG1-NHSester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Mal-PEG1-NHS ester is a PEG linker containing a maleimide group and an NHS ester group. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.

Technology Process of Mal-PEG1-NHS ester

There total 1 articles about Mal-PEG1-NHS ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + 3-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy)propanoic acid (760952-64-5) → 2,5-dioxopyrrolidin-1-yl 3-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy)propanoate (1807518-72-4)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; ethanol; at 20 ℃;

DOI:10.1002/chem.201603617

Reference yield:

2,5-dioxopyrrolidin-1-yl 3-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy)propanoate (1807518-72-4) + 5-[[(2S)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]propanoyl]amino]-2-[[[(1S)-1-[[(1S)-1-[[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl] amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]methylcarbamoyl]-2-methylpropyl]carbamoyl]-2-methylpropyl]methylcarbamoyl]oxymethyl]benzenesulfonic acid trifluoroacetic acid salt → 5-[[(2S)-2-[[(2S)-2-[3-[2-(2,5-dioxopyrrol-1-yl)ethoxy]propanoylamino]-3-methylbutanoyl]amino]propanoyl]amino]-2-[[[(1S)-1-[[(1S)-1-[[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]methylcarbamoyl]-2-methylpropyl]carbamoyl]-2-methylpropyl]methylcarbamoyl]oxymethyl]benzenesulfonic acid

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

2,5-dioxopyrrolidin-1-yl 3-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy)propanoate (1807518-72-4) + [4-[[(2S)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]-5-ureidopentanoyl]amino]-2-sulfophenyl]methyl-[(1S)-1-[[(1S)-1-[[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]methylcarbamoyl]-2-methylpropyl]carbamoyl]-2-methylpropyl]dimethylammonium 2,2,2-trifluoroacetate 2,2,2-trifluoroacetic acid → [4-[[(2S)-2-[[(2S)-2-[3-[2-(2,5-dioxopyrrol-1-yl)ethoxy]propanoylamino]-3-methylbutanoyl]amino]-5-ureidopentanoyl]amino]-2-sulfophenyl]methyl-[(1S)-1-[[(1S)-1-[[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]methylcarbamoyl]-2-methylpropyl]carbamoyl]-2-methylpropyl]dimethylammonium 2,2,2-trifluoroacetate

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

3-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy)propanoic acid

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