2-Cyclohexen-1-one, 4-[(1R,3S,5R)-5-(dimethylphenylsilyl)-1-methyl-3-[(methylsulfonyl)oxy]-2- oxocyclopentyl]-4-methyl-, (4S)-rel-

Base Information

Chemical Name:2-Cyclohexen-1-one, 4-[(1R,3S,5R)-5-(dimethylphenylsilyl)-1-methyl-3-[(methylsulfonyl)oxy]-2- oxocyclopentyl]-4-methyl-, (4S)-rel-
CAS No.:118714-87-7
Molecular Formula:C22H30O5SSi
Molecular Weight:434.629
Hs Code.:
Mol file:118714-87-7.mol

Synonyms:

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Chemical Property of 2-Cyclohexen-1-one, 4-[(1R,3S,5R)-5-(dimethylphenylsilyl)-1-methyl-3-[(methylsulfonyl)oxy]-2- oxocyclopentyl]-4-methyl-, (4S)-rel-

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Technology Process of 2-Cyclohexen-1-one, 4-[(1R,3S,5R)-5-(dimethylphenylsilyl)-1-methyl-3-[(methylsulfonyl)oxy]-2- oxocyclopentyl]-4-methyl-, (4S)-rel-

There total 1 articles about 2-Cyclohexen-1-one, 4-[(1R,3S,5R)-5-(dimethylphenylsilyl)-1-methyl-3-[(methylsulfonyl)oxy]-2- oxocyclopentyl]-4-methyl-, (4S)-rel- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 118714-87-7
4-<5-(dimethylphenylsilyl)-3-<(methylsulfonyl)oxy>-1-methyl-2-oxocyclopentyl>-4-methylcyclohex-2-en-1-one

: Methanesulfonic acid (1R,3S,3aS,4R,8R,8aS)-3-(dimethyl-phenyl-silanyl)-8a-hydroxy-3a,4-dimethyl-7-oxo-1,2,3,3a,4,7,8,8a-octahydro-4,8-methano-azulen-1-yl ester

Guidance literature:: With copper dichloride; In ethanol; for 3h; Ambient temperature;
DOI:10.1021/jo00280a039

Reference yield:

: 75-16-1
methylmagnesium bromide

: 118714-87-7
4-<5-(dimethylphenylsilyl)-3-<(methylsulfonyl)oxy>-1-methyl-2-oxocyclopentyl>-4-methylcyclohex-2-en-1-one

: 118714-88-8
1,4-dimethyl-1-<5-(dimethylphenylsilyl)-3-<(methylsulfonyl)oxy>-1-methyl-2-oxocyclopentyl>-3-cyclohexen-2-one

Guidance literature:: With pyridinium chlorochromate; Yield given. Multistep reaction; 1.) THF, -78 deg C, 3 h, 2.) CH₂Cl₂, room temp., 3 h;
DOI:10.1021/ja00186a057

Reference yield:

: 118714-87-7
4-<5-(dimethylphenylsilyl)-3-<(methylsulfonyl)oxy>-1-methyl-2-oxocyclopentyl>-4-methylcyclohex-2-en-1-one

: 118714-89-9
3,6-dimethyl-6-<5-(dimethylfluorosilyl)-3-<(methylsulfonyl)oxy>-1-methyl-2-oxocyclopentyl>-2-cyclohexen-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran; diethyl ether / 4 h / -78 °C

2: pyridinium chlorochromate / CH₂Cl₂ / 3 h / Ambient temperature

3: 90 percent / 30percent HBF₄*Et₂O / CH₂Cl₂ / 20 h / 50 °C

With tetrafluoroboric acid diethyl ether; pyridinium chlorochromate; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/jo00280a039