Arginyl-Leucine

Base Information

• Chemical Name: Arginyl-Leucine
• CAS No.: 1188-24-5
• Molecular Formula: C12H25N5O3
• Molecular Weight: 287.362
• Hs Code.: 2925290090
• DSSTox Substance ID: DTXSID20426324
• Nikkaji Number: J80.070H
• Wikidata: Q27144131
• Metabolomics Workbench ID: 78686
• Mol file: 1188-24-5.mol

Synonyms:Arg-Leu;Arginyl-Leucine;1188-24-5;L-arginyl-L-leucine;arginylleucine;(2S)-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-4-methylpentanoic acid;L-Leucine, L-arginyl-;RL dipeptide;R-L Dipeptide;L-Arg-L-Leu;Arginine Leucine dipeptide;Arginine-Leucine dipeptide;N-(L-Arginyl)-L-leucine;SCHEMBL3138312;CHEBI:73815;DTXSID20426324;HY-P4268;RL;CS-0653367;Q27144131;(2S)-2-[(2S)-2-amino-5-[(diaminomethylidene)amino]pentanamido]-4-methylpentanoic acid

Chemical Property of Arginyl-Leucine

Chemical Property:

• PSA: 191.62000
• Density: 1.33
• LogP: 1.56550
• Storage Temp.: 2-8°C
• XLogP3: -4
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 9
• Exact Mass: 287.19573968
• Heavy Atom Count: 20
• Complexity: 353

Purity/Quality:

98%,99%, ^*data from raw suppliers

Arg-Leu hydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)CC(C(=O)O)NC(=O)C(CCCN=C(N)N)N
• Isomeric SMILES: CC(C)C[C@@H](C(=O)O)NC(=O)[C@H](CCCN=C(N)N)N
• Recent ClinicalTrials: Lactated Ringer's and PlasmaLyte in Critically Ill Adults

Technology Process of Arginyl-Leucine

There total 22 articles about Arginyl-Leucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-Leu-OMe (2666-93-5) → (S)-2-((S)-2-Amino-5-guanidino-pentanoylamino)-4-methyl-pentanoic acid (1188-24-5)

Guidance literature:

Multi-step reaction with 3 steps

2: aqueous acetone; aqueous NaOH

3: palladium; aqueous HCl; acetic acid / Hydrogenation

With hydrogenchloride; sodium hydroxide; palladium; acetic acid; acetone;

Reference yield:

N5-[imino(nitroamino)methyl]-N2-[(phenylmethoxy)carbonyl]-L-ornithine (2304-98-5) → (S)-2-((S)-2-Amino-5-guanidino-pentanoylamino)-4-methyl-pentanoic acid (1188-24-5)

Guidance literature:

Multi-step reaction with 3 steps

2: aqueous acetone; aqueous NaOH

3: palladium; aqueous HCl; acetic acid / Hydrogenation

With hydrogenchloride; sodium hydroxide; palladium; acetic acid; acetone;

Reference yield:

N-(Nα-benzyloxycarbonyl-Nω-nitro-L-arginyl)-L-leucine (30611-61-1) → (S)-2-((S)-2-Amino-5-guanidino-pentanoylamino)-4-methyl-pentanoic acid (1188-24-5)

Guidance literature:

With palladium; acetic acid; Hydrogenation;

DOI:10.1021/ja01582a065

upstream raw materials:

N-(N^α-benzyloxycarbonyl-N^ω-nitro-L-arginyl)-L-leucine benzyl ester

N-(N^α-benzyloxycarbonyl-N^ω-nitro-L-arginyl)-L-leucine

N-(N^α,N^δ,N^ω-tris-benzyloxycarbonyl-L-arginyl)-L-leucine benzyl ester

L-leucine

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