2-(3-hydroxymethyl-3,3-pentamethyleneacetonyl)-2-trifluoromethylimidazolidine

Base Information

• Chemical Name: 2-(3-hydroxymethyl-3,3-pentamethyleneacetonyl)-2-trifluoromethylimidazolidine
• CAS No.: 204637-04-7
• Molecular Formula: C₁₃H₂₁F₃N₂O₂
• Molecular Weight: 294.317
• Mol file: 204637-04-7.mol

Synonyms:

Chemical Property of 2-(3-hydroxymethyl-3,3-pentamethyleneacetonyl)-2-trifluoromethylimidazolidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-hydroxymethyl-3,3-pentamethyleneacetonyl)-2-trifluoromethylimidazolidine

There total 3 articles about 2-(3-hydroxymethyl-3,3-pentamethyleneacetonyl)-2-trifluoromethylimidazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

ethylenediamine (107-15-3,85404-18-8) + (Z)-3-Amino-4,4,4-trifluoro-1-(1-hydroxymethyl-cyclohexyl)-but-2-en-1-one → 2-(3-hydroxymethyl-3,3-pentamethyleneacetonyl)-2-trifluoromethylimidazolidine (204637-04-7)

Guidance literature:

Ambient temperature;

DOI:10.1007/BF02494288

Reference yield: 40.0%

ethylenediamine (107-15-3,85404-18-8) + (Z)-3-Amino-4,4,4-trifluoro-1-(1-hydroxymethyl-cyclohexyl)-but-2-en-1-one → [1-(7-trifluoromethyl-2,3-dihydro-1H-[1,4]diazepin-5-yl)-cyclohexyl]-methanol (221120-94-1) + 2-(3-hydroxymethyl-3,3-pentamethyleneacetonyl)-2-trifluoromethylimidazolidine (204637-04-7)

Guidance literature:

Yields of byproduct given; Ambient temperature;

DOI:10.1007/BF02494288

Reference yield:

4-hydroxy-3,3-pentamethylenebutan-2-one (78910-84-6) → 2-(3-hydroxymethyl-3,3-pentamethyleneacetonyl)-2-trifluoromethylimidazolidine (204637-04-7)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethylanilinomagnesium bromide

2: Ambient temperature

With N-Ethylanilinomagnesium bromide;

DOI:10.1007/BF02494288

upstream raw materials:

ethylenediamine

4-hydroxy-3,3-pentamethylenebutan-2-one