Technology Process of (2R,3S,4S,5S,6R)-4,5-bis(benzyloxy)-6-((benzyloxy)methyl)-2-methoxy-2-oxido-1,2-oxaphosphinan-3yl acetate
There total 4 articles about (2R,3S,4S,5S,6R)-4,5-bis(benzyloxy)-6-((benzyloxy)methyl)-2-methoxy-2-oxido-1,2-oxaphosphinan-3yl acetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
N,N-dimethyl-formamide;
at 40 ℃;
for 6h;
Inert atmosphere;
DOI:10.1021/ja305104b
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 0.5 h / -78 °C / Inert atmosphere
1.2: 3 h / -78 °C / Inert atmosphere
2.1: N,N-dimethyl-formamide / 6 h / 40 °C / Inert atmosphere
With
sodium hexamethyldisilazane;
In
N,N-dimethyl-formamide;
DOI:10.1021/ja305104b
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium periodate; osmium(VIII) oxide / diethyl ether; water / 6 h / Inert atmosphere
2.1: titanium(IV) isopropylate; (R)-3,3'-diiodo-2,2'-dihydroxy-1,1'-binaphthyl; Cinchonidine / toluene / 0 °C / Inert atmosphere
3.1: sodium hexamethyldisilazane / methanol / 24 h / 20 °C / Inert atmosphere
4.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 0.5 h / -78 °C / Inert atmosphere
4.2: 3 h / -78 °C / Inert atmosphere
5.1: N,N-dimethyl-formamide / 6 h / 40 °C / Inert atmosphere
With
titanium(IV) isopropylate; sodium periodate; osmium(VIII) oxide; sodium hexamethyldisilazane; (R)-3,3'-diiodo-2,2'-dihydroxy-1,1'-binaphthyl; Cinchonidine;
In
methanol; diethyl ether; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ja305104b
