2-Fluoro-N-methyl-4-[7-[(quinolin-6-yl)methyl]imidazo[1,2-b]-[1,2,4]triazin-2-yl]benzamide Dihydrochloride

Base Information

• Chemical Name: 2-Fluoro-N-methyl-4-[7-[(quinolin-6-yl)methyl]imidazo[1,2-b]-[1,2,4]triazin-2-yl]benzamide Dihydrochloride
• CAS No.: 1197376-85-4
• Molecular Formula: C₂₃H₁₇FN₆O*2ClH
• Molecular Weight: 485.348
• Mol file: 1197376-85-4.mol

Synonyms:

Chemical Property of 2-Fluoro-N-methyl-4-[7-[(quinolin-6-yl)methyl]imidazo[1,2-b]-[1,2,4]triazin-2-yl]benzamide Dihydrochloride

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: INCB28060 Dihydrochloride is a novel, ATP-competitive inhibitor of c-MET kinase with an IC50 with 0.13 nM.
• Uses: INCB28060 dihydrochloride exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10, 000-fold selectivity over a large panel of human kinases. This inhibitor potently blocks c-MET phosphorylation and activation of its key downstream effectors in c-MET-dependent tumor cell lines. As a result, INCB 28060 potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis in vitro.

Technology Process of 2-Fluoro-N-methyl-4-[7-[(quinolin-6-yl)methyl]imidazo[1,2-b]-[1,2,4]triazin-2-yl]benzamide Dihydrochloride

There total 5 articles about 2-Fluoro-N-methyl-4-[7-[(quinolin-6-yl)methyl]imidazo[1,2-b]-[1,2,4]triazin-2-yl]benzamide Dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-fluoro-N-methyl-4-[7-(quinolin-6-yl-methyl)-imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide (1029712-80-8) → 2-fluoro-N-methyl-4-[7-(quinolin-6-yl-methyl)-imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide dihydrochloride (1197376-85-4)

Guidance literature:

With hydrogenchloride; In methanol; water; isopropyl alcohol; at 55 ℃; Product distribution / selectivity;

Reference yield:

2-fluoro-N-methyl-4-[7-(quinolin-6-yl-methyl)-imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide (1029712-80-8) → 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide hydrochloride (1197376-85-4)

Guidance literature:

With hydrogenchloride;

Reference yield:

4-(3-amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile (1197377-47-1) → 2-fluoro-N-methyl-4-[7-(quinolin-6-yl-methyl)-imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide dihydrochloride (1197376-85-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: ethylene glycol / 2 h / 110 °C / Large scale

2.1: hydrogenchloride; water / 20 h / 100 °C / Large scale

3.1: 1,1'-carbonyldiimidazole / 1-methyl-pyrrolidin-2-one / 0 °C / Large scale

3.2: 8 h / 15 - 25 °C / Large scale

4.1: hydrogenchloride; pyrographite / water / 0.33 h / 55 - 60 °C / Large scale

With hydrogenchloride; water; pyrographite; 1,1'-carbonyldiimidazole; In 1-methyl-pyrrolidin-2-one; water; ethylene glycol;

upstream raw materials:

2-fluoro-N-methyl-4-[7-(quinolin-6-yl-methyl)-imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide

4-(3-amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile

2-fluoro-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzonitrile

Refernces

• 1、 -. "SALTS OF 2-FLUORO-N-METHYL-4-[7-(QUINOLIN-6-YL-METHYL)-IMIDAZO[1,2-b][1,2,4]TRIAZIN-2-YL]BENZAMIDE AND PROCESSES RELATED TO PREPARING THE SAME". Page/Page column 16-17. . Retrieved 2009/12/05.