6-[ethyl-(2-methoxy-benzyl)-amino]-hexanoic acid [4-(4-{6-[ethyl-(2-methoxy-benzyl)-amino]-hexanoylamino}-benzyl)-phenyl]-amide

Base Information

• Chemical Name: 6-[ethyl-(2-methoxy-benzyl)-amino]-hexanoic acid [4-(4-{6-[ethyl-(2-methoxy-benzyl)-amino]-hexanoylamino}-benzyl)-phenyl]-amide
• CAS No.: 797804-99-0
• Molecular Formula: C₄₅H₆₀N₄O₄
• Molecular Weight: 720.996
• Mol file: 797804-99-0.mol

Synonyms:

Chemical Property of 6-[ethyl-(2-methoxy-benzyl)-amino]-hexanoic acid [4-(4-{6-[ethyl-(2-methoxy-benzyl)-amino]-hexanoylamino}-benzyl)-phenyl]-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-[ethyl-(2-methoxy-benzyl)-amino]-hexanoic acid [4-(4-{6-[ethyl-(2-methoxy-benzyl)-amino]-hexanoylamino}-benzyl)-phenyl]-amide

There total 6 articles about 6-[ethyl-(2-methoxy-benzyl)-amino]-hexanoic acid [4-(4-{6-[ethyl-(2-methoxy-benzyl)-amino]-hexanoylamino}-benzyl)-phenyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

diethyl sulfate (64-67-5) + 6-(2-methoxybenzylamino)hexanoic acid (4-{4-[6-(2-methoxybenzylamino)hexanoylamino]benzyl}phenyl)amide (797805-25-5) → 6-[ethyl-(2-methoxy-benzyl)-amino]-hexanoic acid [4-(4-{6-[ethyl-(2-methoxy-benzyl)-amino]-hexanoylamino}-benzyl)-phenyl]-amide (797804-99-0)

Guidance literature:

In toluene; for 48h; Heating;

DOI:10.1021/jm0494366

Reference yield:

6-(benzyloxycarbonylamino)hexanoic acid (1947-00-8) → 6-[ethyl-(2-methoxy-benzyl)-amino]-hexanoic acid [4-(4-{6-[ethyl-(2-methoxy-benzyl)-amino]-hexanoylamino}-benzyl)-phenyl]-amide (797804-99-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: ethyl chloroformate; Et₃N / dioxane / 0.5 h

1.2: 83 percent / dioxane / 72 h / 20 °C

2.1: 100 percent / HBr; AcOH / 4 h / 20 °C

3.1: toluene / 6 h / Heating

4.1: NaBH₄ / ethanol / 6 h / 20 °C

5.1: 16 percent / toluene / 48 h / Heating

With sodium tetrahydroborate; hydrogen bromide; chloroformic acid ethyl ester; acetic acid; triethylamine; In 1,4-dioxane; ethanol; toluene;

DOI:10.1021/jm0494366

Reference yield:

4,4'-diamino diphenyl methane (101-77-9) → 6-[ethyl-(2-methoxy-benzyl)-amino]-hexanoic acid [4-(4-{6-[ethyl-(2-methoxy-benzyl)-amino]-hexanoylamino}-benzyl)-phenyl]-amide (797804-99-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: ethyl chloroformate; Et₃N / dioxane / 0.5 h

1.2: 83 percent / dioxane / 72 h / 20 °C

2.1: 100 percent / HBr; AcOH / 4 h / 20 °C

3.1: toluene / 6 h / Heating

4.1: NaBH₄ / ethanol / 6 h / 20 °C

5.1: 16 percent / toluene / 48 h / Heating

With sodium tetrahydroborate; hydrogen bromide; chloroformic acid ethyl ester; acetic acid; triethylamine; In 1,4-dioxane; ethanol; toluene;

DOI:10.1021/jm0494366

upstream raw materials:

diethyl sulfate

6-(2-methoxybenzylamino)hexanoic acid (4-{4-[6-(2-methoxybenzylamino)hexanoylamino]benzyl}phenyl)amide

6-(benzyloxycarbonylamino)hexanoic acid

4,4'-diamino diphenyl methane