Technology Process of 5-[3,5-bis(trifluoromethyl)phenyl]-3-{[4'-fluoro-2'-methoxy-5'-(propan-2-yl)-4-(trifluoromethyl)biphenyl-2-yl]methyl}-4,4-dimethyl-1,3-oxazolidin-2-one
There total 17 articles about 5-[3,5-bis(trifluoromethyl)phenyl]-3-{[4'-fluoro-2'-methoxy-5'-(propan-2-yl)-4-(trifluoromethyl)biphenyl-2-yl]methyl}-4,4-dimethyl-1,3-oxazolidin-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
benzyl {2-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxy-1,1-dimethylethyl}carbamate;
With
sodium hydride;
In
N,N-dimethyl-formamide;
at 25 ℃;
for 0.25h;
Inert atmosphere;
2'-(bromomethyl)-4-fluoro-2-methoxy-5-(propan-2-yl)-4'-(trifluoromethyl)biphenyl;
In
N,N-dimethyl-formamide;
at 25 ℃;
for 15h;
Inert atmosphere;
DOI:10.1021/jm200484c
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere
2.1: methanesulfonyl chloride; triethylamine / dichloromethane / 0 - 25 °C / Inert atmosphere
3.1: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 25 °C / 760.05 Torr
4.1: iodine; silver sulfate / methanol / 3 h / 25 °C
5.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C / Inert atmosphere
5.2: 3 h / -78 °C / Inert atmosphere
6.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / ethanol; water; benzene / 24 h / Inert atmosphere; Reflux
7.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 0 - 25 °C / Inert atmosphere
8.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 25 °C / Inert atmosphere
8.2: 15 h / 25 °C / Inert atmosphere
With
tetrakis(triphenylphosphine) palladium(0); n-butyllithium; carbon tetrabromide; palladium 10% on activated carbon; hydrogen; iodine; sodium hydride; sodium carbonate; silver sulfate; methanesulfonyl chloride; triethylamine; triphenylphosphine;
In
tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm200484c
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 4 h / -78 °C / Inert atmosphere
2.1: tetrahydrofuran / 3 h / -20 - 25 °C
3.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 25 °C / Inert atmosphere
3.2: 15 h / 25 °C / Inert atmosphere
With
sodium hydride; diisobutylaluminium hydride;
In
tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm200484c
