Technology Process of SRC 689
There total 4 articles about SRC 689 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
dmap; triethylamine;
In
dichloromethane;
at 0 - 20 ℃;
for 18h;
Inert atmosphere;
DOI:10.1021/ol201643v
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / 21 - 22 °C / Inert atmosphere
1.2: 4.5 h / -20 - 20 °C / Inert atmosphere
2.1: formic acid; N-[(1R,2R)-1,2-diphenyl-2-(3-phenylpropylamino)ethyl]-4-methylbenzene sulfonamide ammonium chloride ruthenium; triethylamine / 24 h / 28 °C / Inert atmosphere
3.1: dmap; triethylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere
With
dmap; formic acid; N-[(1R,2R)-1,2-diphenyl-2-(3-phenylpropylamino)ethyl]-4-methylbenzene sulfonamide ammonium chloride ruthenium; potassium tert-butylate; triethylamine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/ol201643v
- Guidance literature:
-
Multi-step reaction with 2 steps
1: formic acid; N-[(1R,2R)-1,2-diphenyl-2-(3-phenylpropylamino)ethyl]-4-methylbenzene sulfonamide ammonium chloride ruthenium; triethylamine / 24 h / 28 °C / Inert atmosphere
2: dmap; triethylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere
With
dmap; formic acid; N-[(1R,2R)-1,2-diphenyl-2-(3-phenylpropylamino)ethyl]-4-methylbenzene sulfonamide ammonium chloride ruthenium; triethylamine;
In
dichloromethane;
DOI:10.1021/ol201643v
