Technology Process of (1R,6S)-6-((S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionylamino)-cyclohex-3-enecarboxylic acid methyl ester
There total 19 articles about (1R,6S)-6-((S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionylamino)-cyclohex-3-enecarboxylic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 98 percent / pig liver esterase (PLE) / 3 h / 30 °C / solvents: buffers (pH 6.8 and pH 8), aceton
2: 1.) ethyl chloroformate, Et3N 2.) NaN3 / 1.) aceton, -25 deg C 2.) 1h, r. t.
3: benzene / 2 h / Heating
4: 91 percent / p-TosOH / benzene / 1 h / Heating
5: 55 percent / NaOMe / methanol / 6 h / Heating
6: H2 / 10percent Pd-C / methanol / 4 h / Ambient temperature
7: pyridine / CCl4 / 4 h / Ambient temperature
With
pyridine; sodium azide; pig liver esterase; hydrogen; sodium methylate; chloroformic acid ethyl ester; toluene-4-sulfonic acid; triethylamine;
palladium on activated charcoal;
In
methanol; tetrachloromethane; benzene;
DOI:10.1248/cpb.38.350
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 98 percent / pig liver esterase (PLE) / 3 h / 30 °C / solvents: buffers (pH 6.8 and pH 8), aceton
2: 1.) ethyl chloroformate, Et3N 2.) NaN3 / 1.) aceton, -25 deg C 2.) 1h, r. t.
3: benzene / 2 h / Heating
4: 91 percent / p-TosOH / benzene / 1 h / Heating
5: H2 / 10percent Pd-C / methanol / 4 h / Ambient temperature
6: pyridine / CCl4 / 4 h / Ambient temperature
With
pyridine; sodium azide; pig liver esterase; hydrogen; chloroformic acid ethyl ester; toluene-4-sulfonic acid; triethylamine;
palladium on activated charcoal;
In
methanol; tetrachloromethane; benzene;
DOI:10.1248/cpb.38.350
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 98 percent / pig liver esterase (PLE) / 3 h / 30 °C / solvents: buffers (pH 6.8 and pH 8), aceton
2: 1.) ethyl chloroformate, Et3N 2.) NaN3 / 1.) aceton, -25 deg C 2.) 1h, r. t.
3: benzene / 2 h / Heating
4: 91 percent / p-TosOH / benzene / 1 h / Heating
5: H2 / 10percent Pd-C / methanol / 4 h / Ambient temperature
6: pyridine / CCl4 / 4 h / Ambient temperature
With
pyridine; sodium azide; pig liver esterase; hydrogen; chloroformic acid ethyl ester; toluene-4-sulfonic acid; triethylamine;
palladium on activated charcoal;
In
methanol; tetrachloromethane; benzene;
DOI:10.1248/cpb.38.350
