3-Cyclohexene-1-carboxylicacid,6-amino-,methylester,(1S,6R)-(9CI)

Base Information

Chemical Name:3-Cyclohexene-1-carboxylicacid,6-amino-,methylester,(1S,6R)-(9CI)
CAS No.:758681-72-0
Molecular Formula:C₈H₁₃NO₂
Molecular Weight:155.197
Hs Code.:
Mol file:758681-72-0.mol

Synonyms:3-Cyclohexene-1-carboxylicacid,6-amino-,methylester,(1S,6R)-(9CI)

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Chemical Property of 3-Cyclohexene-1-carboxylicacid,6-amino-,methylester,(1S,6R)-(9CI)

Chemical Property:

PSA：52.32000
LogP:1.15320

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 3-Cyclohexene-1-carboxylicacid,6-amino-,methylester,(1S,6R)-(9CI)

There total 5 articles about 3-Cyclohexene-1-carboxylicacid,6-amino-,methylester,(1S,6R)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 91259-90-4
(1S,6R)-6-Benzyloxycarbonylamino-cyclohex-3-ene-1-carboxylic acid methyl ester

: 758681-72-0
(1S,6R)-6-Amino-cyclohex-3-enecarboxylic acid methyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 4h; Ambient temperature;
DOI:10.1248/cpb.38.350

Reference yield:

: 4841-84-3
dimethyl cis-1,2,3,6-tetrahydrophthalate

: 758681-72-0
(1S,6R)-6-Amino-cyclohex-3-enecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / pig liver esterase (PLE) / 3 h / 30 °C / solvents: buffers (pH 6.8 and pH 8), aceton

2: 1.) ethyl chloroformate, Et₃N 2.) NaN₃ / 1.) aceton, -25 deg C 2.) 1h, r. t.

3: benzene / 2 h / Heating

4: 91 percent / p-TosOH / benzene / 1 h / Heating

5: H₂ / 10percent Pd-C / methanol / 4 h / Ambient temperature

With sodium azide; pig liver esterase; hydrogen; chloroformic acid ethyl ester; toluene-4-sulfonic acid; triethylamine; palladium on activated charcoal; In methanol; benzene;
DOI:10.1248/cpb.38.350

Reference yield:

: 31139-02-3,31139-03-4,56124-48-2,88335-93-7,88335-94-8,93603-11-3
(1R,6S)-6-methoxycarbonyl-3-cyclohexene-1-carboxylic acid

: 758681-72-0
(1S,6R)-6-Amino-cyclohex-3-enecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) ethyl chloroformate, Et₃N 2.) NaN₃ / 1.) aceton, -25 deg C 2.) 1h, r. t.

2: benzene / 2 h / Heating

3: 91 percent / p-TosOH / benzene / 1 h / Heating

4: H₂ / 10percent Pd-C / methanol / 4 h / Ambient temperature

With sodium azide; hydrogen; chloroformic acid ethyl ester; toluene-4-sulfonic acid; triethylamine; palladium on activated charcoal; In methanol; benzene;
DOI:10.1248/cpb.38.350