C₁₆H₁₅N₃O₃S

Base Information

• Chemical Name: C₁₆H₁₅N₃O₃S
• CAS No.: 1802571-63-6
• Molecular Formula: C₁₆H₁₅N₃O₃S
• Molecular Weight: 329.379
• Mol file: 1802571-63-6.mol

Synonyms:

Chemical Property of C₁₆H₁₅N₃O₃S

Chemical Property:

Purity/Quality:

4-Methyl-N'-(1-methyl-2-oxo-1,2-dihydro-3H-indol-3-yliden)benzenesulfonohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₆H₁₅N₃O₃S

There total 5 articles about C₁₆H₁₅N₃O₃S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

1-methyl-1H-indole-2,3-dione (2058-74-4) + toluene-4-sulfonic acid hydrazide (1576-35-8) → N-methyl-3-tosylhydrazono-2-oxindole (3265-25-6,1802571-63-6)

Guidance literature:

In tetrahydrofuran; for 1h; Reflux;

DOI:10.3762/BJOC.17.47

Reference yield:

indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) → N-methyl-3-tosylhydrazono-2-oxindole (3265-25-6,1802571-63-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

1.2: 20 °C

2.1: methanol / 65 °C

With sodium hydride; In methanol; N,N-dimethyl-formamide;

DOI:10.1002/ejoc.201101625

Reference yield:

1-methyl-1H-indole-2,3-dione (2058-74-4) + toluene-4-sulfonic acid hydrazide (1576-35-8) → C16H15N3O3S (1802571-63-6)

Guidance literature:

In methanol; at 70 ℃; for 0.583333h; diastereoselective reaction;

DOI:10.1002/ejoc.201500340

upstream raw materials:

1-methyl-1H-indole-2,3-dione

toluene-4-sulfonic acid hydrazide

indole-2,3-dione

Downstream raw materials:

1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl benzoate

Refernces

• 1、 Zhang, Jun,Wang, Mengmeng,Wang, Huiying,Xu, Hui,Chen, Junjie,Guo, Ziqiong,Ma, Biao,Ban, Shu-Rong,Dai, Hui-Xiong. "Construction of 2-alkynyl aza-spiro[4,5]indole scaffolds: Via sequential C-H activations for modular click chemistry libraries". supporting information. p. 8656 - 8659. Retrieved 2021/09/04.
• 2、 Empel, Claire,Jana, Sripati,Koenigs, Rene M.,Verspeek, Dennis. "Photochemical O?H Functionalization Reactions of Cyclic Diazoamides". supporting information. p. 4716 - 4722. Retrieved 2020/09/23.