11-[2-Methoxy-4-(methyl-prop-2-ynyl-amino)-phenyl]-5,8,9,10,11,12-hexahydro-6H-7,12-diaza-cyclonona[a]indene-7,11-dicarboxylic acid 11-methyl ester 7-phenyl ester

Base Information

• Chemical Name: 11-[2-Methoxy-4-(methyl-prop-2-ynyl-amino)-phenyl]-5,8,9,10,11,12-hexahydro-6H-7,12-diaza-cyclonona[a]indene-7,11-dicarboxylic acid 11-methyl ester 7-phenyl ester
• CAS No.: 123871-19-2
• Molecular Formula: C₃₄H₃₅N₃O₅
• Molecular Weight: 565.669
• Mol file: 123871-19-2.mol

Synonyms:

Chemical Property of 11-[2-Methoxy-4-(methyl-prop-2-ynyl-amino)-phenyl]-5,8,9,10,11,12-hexahydro-6H-7,12-diaza-cyclonona[a]indene-7,11-dicarboxylic acid 11-methyl ester 7-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 11-[2-Methoxy-4-(methyl-prop-2-ynyl-amino)-phenyl]-5,8,9,10,11,12-hexahydro-6H-7,12-diaza-cyclonona[a]indene-7,11-dicarboxylic acid 11-methyl ester 7-phenyl ester

There total 2 articles about 11-[2-Methoxy-4-(methyl-prop-2-ynyl-amino)-phenyl]-5,8,9,10,11,12-hexahydro-6H-7,12-diaza-cyclonona[a]indene-7,11-dicarboxylic acid 11-methyl ester 7-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2,3,6,11-tetrahydro-1H,5H-indolizino[8,7-b]indole-11b-carboxylic acid methyl ester (79888-14-5) + phenyl chloroformate (1885-14-9) + 3-methoxy-N-methyl-N-(prop-2-yn-1-yl)aniline (123871-18-1) → 11-[2-Methoxy-4-(methyl-prop-2-ynyl-amino)-phenyl]-5,8,9,10,11,12-hexahydro-6H-7,12-diaza-cyclonona[a]indene-7,11-dicarboxylic acid 11-methyl ester 7-phenyl ester (123871-19-2)

Guidance literature:

In dichloromethane;

DOI:10.1039/c39890000518

Reference yield:

3-methoxy-N-methylaniline (14318-66-2) → 11-[2-Methoxy-4-(methyl-prop-2-ynyl-amino)-phenyl]-5,8,9,10,11,12-hexahydro-6H-7,12-diaza-cyclonona[a]indene-7,11-dicarboxylic acid 11-methyl ester 7-phenyl ester (123871-19-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / K₂CO₃ / acetonitrile

2: 78 percent / CH₂Cl₂

With potassium carbonate; In dichloromethane; acetonitrile;

DOI:10.1039/c39890000518

Reference yield:

11-[2-Methoxy-4-(methyl-prop-2-ynyl-amino)-phenyl]-5,8,9,10,11,12-hexahydro-6H-7,12-diaza-cyclonona[a]indene-7,11-dicarboxylic acid 11-methyl ester 7-phenyl ester (123871-19-2) → 11-[4-(Formyl-methyl-amino)-2-methoxy-phenyl]-5,8,9,10,11,12-hexahydro-6H-7,12-diaza-cyclonona[a]indene-7,11-dicarboxylic acid 11-methyl ester 7-phenyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Co₂(CO)8; 2.) trifluoroacetic acid / 1.) EtOAc; 2.) 25 deg C

2: 55 percent / acetic anhydride

With dicobalt octacarbonyl; trifluoroacetic acid; In acetic anhydride;

DOI:10.1039/c39890000518

upstream raw materials:

2,3,6,11-tetrahydro-1H,5H-indolizino[8,7-b]indole-11b-carboxylic acid methyl ester

phenyl chloroformate

3-methoxy-N-methyl-N-(prop-2-yn-1-yl)aniline

3-methoxy-N-methylaniline