2-methylene 3-oxo cyclohexane carbonitrile

Base Information

• Chemical Name: 2-methylene 3-oxo cyclohexane carbonitrile
• CAS No.: 112496-83-0
• Molecular Formula: C₈H₉NO
• Molecular Weight: 135.166
• Mol file: 112496-83-0.mol

Synonyms:

Chemical Property of 2-methylene 3-oxo cyclohexane carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methylene 3-oxo cyclohexane carbonitrile

There total 4 articles about 2-methylene 3-oxo cyclohexane carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-oxo 2-phenylsulfonylmethyl cyclohexane carbonitrile (112496-80-7) → 2-methylene 3-oxo cyclohexane carbonitrile (112496-83-0)

Guidance literature:

With aluminum oxide; In dichloromethane; for 0.333333h; Yield given;

DOI:10.1016/S0040-4020(01)89959-2

Reference yield:

cyclohexenone (930-68-7) → 2-methylene 3-oxo cyclohexane carbonitrile (112496-83-0)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylaluminium / hexane / 0.5 h / 60 °C

2: dry ZnBr₂ / CH₂Cl₂ / 18 h / Ambient temperature

3: oxone (2KHSO₅, KHSO₄, K₂SO₄) / methanol; H₂O / 4 h / Ambient temperature

4: basic alumina (Al₂O₃) / CH₂Cl₂ / 0.33 h

With aluminum oxide; Oxone; triethylaluminum; zinc dibromide; In methanol; hexane; dichloromethane; water;

DOI:10.1016/S0040-4020(01)89959-2

Reference yield:

3-trimethylsiloxy-2-cyclohexene-1-carbonitrile (66885-88-9) → 2-methylene 3-oxo cyclohexane carbonitrile (112496-83-0)

Guidance literature:

Multi-step reaction with 3 steps

1: dry ZnBr₂ / CH₂Cl₂ / 18 h / Ambient temperature

2: oxone (2KHSO₅, KHSO₄, K₂SO₄) / methanol; H₂O / 4 h / Ambient temperature

3: basic alumina (Al₂O₃) / CH₂Cl₂ / 0.33 h

With aluminum oxide; Oxone; zinc dibromide; In methanol; dichloromethane; water;

DOI:10.1016/S0040-4020(01)89959-2

upstream raw materials:

3-oxo 2-phenylsulfonylmethyl cyclohexane carbonitrile

cyclohexenone

3-trimethylsiloxy-2-cyclohexene-1-carbonitrile

3-oxo 2-phenylthiomethyl cyclohexane carbonitrile