[tert-butoxycarbonyl-(1-cyclohexylmethyl-2-oxo-2-{2-[(6-thiocarbamoyl-pyridin-3-ylmethyl)-carbamoyl]-2,5-dihydro-pyrrol-1-yl}-ethyl)-amino]-acetic acid tert-butyl ester

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Chemical Name:[tert-butoxycarbonyl-(1-cyclohexylmethyl-2-oxo-2-{2-[(6-thiocarbamoyl-pyridin-3-ylmethyl)-carbamoyl]-2,5-dihydro-pyrrol-1-yl}-ethyl)-amino]-acetic acid tert-butyl ester
CAS No.:182291-44-7
Molecular Formula:C₃₂H₄₇N₅O₆S
Molecular Weight:629.821
Hs Code.:

[<i>tert</i>-butoxycarbonyl-(1-cyclohexylmethyl-2-oxo-2-{2-[(6-thiocarbamoyl-pyridin-3-ylmethyl)-carbamoyl]-2,5-dihydro-pyrrol-1-yl}-ethyl)-amino]-acetic acid <i>tert</i>-butyl ester

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Chemical Property of [tert-butoxycarbonyl-(1-cyclohexylmethyl-2-oxo-2-{2-[(6-thiocarbamoyl-pyridin-3-ylmethyl)-carbamoyl]-2,5-dihydro-pyrrol-1-yl}-ethyl)-amino]-acetic acid tert-butyl ester

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Technology Process of [tert-butoxycarbonyl-(1-cyclohexylmethyl-2-oxo-2-{2-[(6-thiocarbamoyl-pyridin-3-ylmethyl)-carbamoyl]-2,5-dihydro-pyrrol-1-yl}-ethyl)-amino]-acetic acid tert-butyl ester

There total 25 articles about [tert-butoxycarbonyl-(1-cyclohexylmethyl-2-oxo-2-{2-[(6-thiocarbamoyl-pyridin-3-ylmethyl)-carbamoyl]-2,5-dihydro-pyrrol-1-yl}-ethyl)-amino]-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67515-95-1
5-chlorocarbonyl-pyridine-2-carboxylic acid ethyl ester

: 182291-44-7
[tert-butoxycarbonyl-(1-cyclohexylmethyl-2-oxo-2-{2-[(6-thiocarbamoyl-pyridin-3-ylmethyl)-carbamoyl]-2,5-dihydro-pyrrol-1-yl}-ethyl)-amino]-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 11 steps

1.1: NH₃ / tetrahydrofuran / -10 °C

2.1: (CF₃CO)2); i-Pr₂NEt / CH₂Cl₂ / 20 °C

3.1: NH₃ / ethanol / -10 °C

4.1: 93 percent / aq. HCl; H₂ / Pd/C / propan-1-ol / 6 h / 1500.12 Torr

5.1: 90 percent / aq. NaOH / methanol / 50 - 55 °C

6.1: Et₃N / CH₂Cl₂; trifluoroacetic acid / 1 h / 20 - 25 °C

7.1: 47.3 kg / aq. HCl / propan-2-ol / 18 h

8.1: i-Pr₂NEt; propane phosphonic acid anhydride / CH₂Cl₂; ethyl acetate / 13 h / -25 - -5 °C

9.1: 43 kg / aq. HCl / propan-2-ol / 17 h / 20 - 50 °C

10.1: aq. HCl / CH₂Cl₂ / pH 2 - 3

10.2: 95 percent / N-ethyl-N,N-diisopropylamine; propane phosphonic acid anhydride / ethyl acetate / 13 h / 0 - 25 °C

11.1: H₂S; Et₃N; pyridine / 20 °C

With pyridine; hydrogenchloride; sodium hydroxide; 1,1,1,4,4,4-hexafluoro-2,3-butanedione; propylphosphonic anhydride; hydrogen sulfide; ammonia; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; propan-1-ol; ethanol; dichloromethane; ethyl acetate; isopropyl alcohol; trifluoroacetic acid;
DOI:10.1055/s-2004-831200

Reference yield:

: 5-carbamoyl-pyridine-2-carboxylic acid ethyl ester

: 182291-44-7
[tert-butoxycarbonyl-(1-cyclohexylmethyl-2-oxo-2-{2-[(6-thiocarbamoyl-pyridin-3-ylmethyl)-carbamoyl]-2,5-dihydro-pyrrol-1-yl}-ethyl)-amino]-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: (CF₃CO)2); i-Pr₂NEt / CH₂Cl₂ / 20 °C

2.1: NH₃ / ethanol / -10 °C

3.1: 93 percent / aq. HCl; H₂ / Pd/C / propan-1-ol / 6 h / 1500.12 Torr

4.1: 90 percent / aq. NaOH / methanol / 50 - 55 °C

5.1: Et₃N / CH₂Cl₂; trifluoroacetic acid / 1 h / 20 - 25 °C

6.1: 47.3 kg / aq. HCl / propan-2-ol / 18 h

7.1: i-Pr₂NEt; propane phosphonic acid anhydride / CH₂Cl₂; ethyl acetate / 13 h / -25 - -5 °C

8.1: 43 kg / aq. HCl / propan-2-ol / 17 h / 20 - 50 °C

9.1: aq. HCl / CH₂Cl₂ / pH 2 - 3

9.2: 95 percent / N-ethyl-N,N-diisopropylamine; propane phosphonic acid anhydride / ethyl acetate / 13 h / 0 - 25 °C

10.1: H₂S; Et₃N; pyridine / 20 °C

With pyridine; hydrogenchloride; sodium hydroxide; 1,1,1,4,4,4-hexafluoro-2,3-butanedione; propylphosphonic anhydride; hydrogen sulfide; ammonia; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; propan-1-ol; ethanol; dichloromethane; ethyl acetate; isopropyl alcohol; trifluoroacetic acid;
DOI:10.1055/s-2004-831200

Reference yield:

: 65346-04-5
5-cyano-2-pyridinecarboxamide

: 182291-44-7
[tert-butoxycarbonyl-(1-cyclohexylmethyl-2-oxo-2-{2-[(6-thiocarbamoyl-pyridin-3-ylmethyl)-carbamoyl]-2,5-dihydro-pyrrol-1-yl}-ethyl)-amino]-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: 93 percent / aq. HCl; H₂ / Pd/C / propan-1-ol / 6 h / 1500.12 Torr

2.1: 90 percent / aq. NaOH / methanol / 50 - 55 °C

3.1: Et₃N / CH₂Cl₂; trifluoroacetic acid / 1 h / 20 - 25 °C

4.1: 47.3 kg / aq. HCl / propan-2-ol / 18 h

5.1: i-Pr₂NEt; propane phosphonic acid anhydride / CH₂Cl₂; ethyl acetate / 13 h / -25 - -5 °C

6.1: 43 kg / aq. HCl / propan-2-ol / 17 h / 20 - 50 °C

7.1: aq. HCl / CH₂Cl₂ / pH 2 - 3

7.2: 95 percent / N-ethyl-N,N-diisopropylamine; propane phosphonic acid anhydride / ethyl acetate / 13 h / 0 - 25 °C

8.1: H₂S; Et₃N; pyridine / 20 °C

With pyridine; hydrogenchloride; sodium hydroxide; propylphosphonic anhydride; hydrogen sulfide; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; propan-1-ol; dichloromethane; ethyl acetate; isopropyl alcohol; trifluoroacetic acid;
DOI:10.1055/s-2004-831200