65346-04-5

Basic information

• Product Name: 2-Pyridinecarboxamide,5-cyano-(9CI)
• Synonyms: 2-Pyridinecarboxamide,5-cyano-(9CI);5-cyanopicolinamide;2-Pyridinecarboxamide,5-cyano
• CAS NO: 65346-04-5
• Molecular Formula: C₇H₅N₃O
• Molecular Weight: 147.1341
• Product Categories: AMIDE
• Mol File: 65346-04-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 379 °C at 760 mmHg
• Flash Point: 183 °C
• Appearance: /
• Density: 1.33 g/cm³
• Vapor Pressure: 6.02E-06mmHg at 25°C
• Refractive Index: 1.596
• CAS DataBase Reference: 2-Pyridinecarboxamide,5-cyano-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinecarboxamide,5-cyano-(9CI)(65346-04-5)
• EPA Substance Registry System: 2-Pyridinecarboxamide,5-cyano-(9CI)(65346-04-5)

Safety Data

• Hazardous Substances Data: 65346-04-5(Hazardous Substances Data)

Usage

General Description

2-Pyridinecarboxamide, 5-cyano-(9CI) is a chemical compound with the molecular formula C7H5N3O. It is a derivative of pyridinecarboxamide with a cyano group attached to the 5th carbon atom of the pyridine ring. It is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. 2-Pyridinecarboxamide,5-cyano-(9CI) is also known for its role in the production of heterocyclic compounds, which are widely used in the pharmaceutical industry. It is important to handle this chemical with care and follow proper safety protocols, as it may have potential health hazards if not handled properly.

InChI:InChI=1/C7H5N3O/c8-3-5-1-2-6(7(9)11)10-4-5/h1-2,4H,(H2,9,11)

Upstream product

• 100-54-9 pyridine-3-carbonitrile 
• 77287-34-4 formamide 
• 53234-55-2 5-cyano-pyridine-2-carboxylic acid 
• 17874-78-1 6-ethoxycarbonylpyridine-3-carboxylic acid 
• 100-26-5 Pyridine-2,5-dicarboxylic acid 
• 67515-95-1 5-chlorocarbonyl-pyridine-2-carboxylic acid ethyl ester 
• 41051-03-0 ethyl 5-cyano-2-pyridinecarboxylate 

Downstream Products

• 788801-45-6 [tert-butoxycarbonyl-(1-cyclohexylmethyl-2-{2-[(6-methylsulfanylcarbonimidoyl-pyridin-3-ylmethyl)-carbamoyl]-2,5-dihydro-pyrrol-1-yl}-2-oxo-ethyl)-amino]-acetic acid tert-butyl ester 
• 182291-44-7 [tert-butoxycarbonyl-(1-cyclohexylmethyl-2-oxo-2-{2-[(6-thiocarbamoyl-pyridin-3-ylmethyl)-carbamoyl]-2,5-dihydro-pyrrol-1-yl}-ethyl)-amino]-acetic acid tert-butyl ester 
• 182291-43-6 tert-butyl {(tert-butoxycarbonyl)[(1R)-2-[(2S)-2-({[(6-cyano-3-pyridinyl)methyl]amino}carbonyl)-2,5-dihydro-1H-pyrrol-1-yl]-1-(cyclohexylmethyl)-2-oxoethyl]amino}acetate 
• 182159-74-6 ((R)-2-{(S)-2-[(6-Carbamoyl-pyridin-3-ylmethyl)-carbamoyl]-2,5-dihydro-pyrrol-1-yl}-1-cyclohexylmethyl-2-oxo-ethyl)-carbamic acid tert-butyl ester 
• 182291-42-5 ((R)-2-{(S)-2-[(6-Cyano-pyridin-3-ylmethyl)-carbamoyl]-2,5-dihydro-pyrrol-1-yl}-1-cyclohexylmethyl-2-oxo-ethylamino)-acetic acid tert-butyl ester 
• 182159-75-7 ((R)-2-{(S)-2-[(6-Cyano-pyridin-3-ylmethyl)-carbamoyl]-2,5-dihydro-pyrrol-1-yl}-1-cyclohexylmethyl-2-oxo-ethyl)-carbamic acid tert-butyl ester 
• 302341-61-3 tert-bulyl N-[(6-cyanopyridin-3-yl)methyl]carbamate 

Relevant articles and documents

Transition-metal-free synthesis of primary to tertiary carboxamides: A quick access to prodrug-pyrazinecarboxamide

One-pot expedient and direct carbamoylation of heterocyclics is described. The transformation is realized via direct dehydrogenative aminocarbonylation of heterocyclic compounds under transition-metal-free conditions. This method is regioselective and the protocol is proved to be scalable on a gram scale. Further, the therapeutically useful antitubercular agent pyrazinecarboxamide is successfully synthesized by employing this protocol.

PERFLUORINATED 5,6-DIHYDRO-4H-1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE

The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A4, A5, A6, A8, each of R1 and R2, R3 and R7 of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas II and III, and sub-formula embodiments thereof, intermediates and processes and methods useful for the preparation of compounds of Formulas I-III.

A Simple Synthesis of 5-Cyano-2-pyridinecarboxylic Acid and its Amide

The title compounds 3 and 2 (X = CN) are prepared in good yields by regioselective carbamoylation of 3-cyanopyridine in a Minisci reaction and by consecutive amide hydrolysis with amyl nitrite in HCl-saturated acetic acid.The observed regioselectivity apparently remains confined to carbamoyl and possibly acyl radicals and to -M-effect substituents in 3-position.