ETHYL 1-HYDROXYMETHYLCYCLOBUTANECARBOXYLATE

Base Information

• Chemical Name: ETHYL 1-HYDROXYMETHYLCYCLOBUTANECARBOXYLATE
• CAS No.: 1195-81-9
• Molecular Formula: C8H14O3
• Molecular Weight: 158.197
• Hs Code.: 2918199090
• Mol file: 1195-81-9.mol

Synonyms:ethyl 1-(hydroxymethyl)cyclobutanecarboxylate;1-Hydroxymethyl-cyclobutancarbonsaeure-aethylester;Cyclobutanecarboxylic acid,1-(hydroxymethyl)-,ethyl ester;1-hydroxymethyl-cyclobutanecarboxylic acid ethyl ester;

Chemical Property of ETHYL 1-HYDROXYMETHYLCYCLOBUTANECARBOXYLATE

Chemical Property:

• PSA: 46.53000
• LogP: 0.71210

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ethyl1-(Hydroxymethyl)cyclobutane-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 1-HYDROXYMETHYLCYCLOBUTANECARBOXYLATE

There total 3 articles about ETHYL 1-HYDROXYMETHYLCYCLOBUTANECARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

diethyl cyclobutane-1,1-dicarboxylate (3779-29-1) → ethyl 1-(hydroxymethyl)cyclobutanecarboxylate (1195-81-9)

Guidance literature:

diethyl cyclobutane-1,1-dicarboxylate; With lithium tri-t-butoxyaluminum hydride; In tetrahydrofuran; at -78 - 20 ℃; for 14h;

With potassium hydrogensulfate; In tetrahydrofuran; water;

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + ethyl cyclobutylcarboxylate (14924-53-9) → ethyl 1-(hydroxymethyl)cyclobutanecarboxylate (1195-81-9)

Guidance literature:

ethyl cyclobutylcarboxylate; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at 0 ℃; for 1h; Inert atmosphere;

formaldehyd; In tetrahydrofuran; hexane; at 0 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1055/s-0029-1217703

Reference yield:

→ ethyl 1-(hydroxymethyl)cyclobutanecarboxylate (1195-81-9)

Guidance literature:

Cyclobutan-1,1-dicarbonsaeure-aethylester-chlorid, NaBH4, Dioxan, Δ;

upstream raw materials:

diethyl cyclobutane-1,1-dicarboxylate

formaldehyd

ethyl cyclobutylcarboxylate

Downstream raw materials:

(1-ethenylcyclobutyl)diphenylmethanol

ethyl 4-(2-cyclobutylidenethyl)benzoate

C₁₅H₂₀O₃

C₁₃H₁₅ClO₂

Refernces

• 1、 -. "Compounds Which Selectively Modulate The CB2 Receptor". Page/Page column 55-56. . Retrieved 2010/04/23.
• 2、 Iwasaki, Masayuki,Yorimitsu, Hideki,Oshima, Koichiro. "Synthesis of (2-arylethylidene)cyclobutanes by palladium-catalyzed reactions of aryl halides with homoallyl alcohols bearing a trimethylene group at the allylic position". supporting information; experimental part. p. 2177 - 2179. Retrieved 2011/03/20.