(S)-N-(1',1'-Dimethylethyl)-2-methoxy-2-phenyl-3,3,3-trifluoropropionamide

Base Information

• Chemical Name: (S)-N-(1',1'-Dimethylethyl)-2-methoxy-2-phenyl-3,3,3-trifluoropropionamide
• CAS No.: 150723-33-4
• Molecular Formula: C₁₄H₁₈F₃NO₂
• Molecular Weight: 289.298
• Mol file: 150723-33-4.mol

Synonyms:

Chemical Property of (S)-N-(1',1'-Dimethylethyl)-2-methoxy-2-phenyl-3,3,3-trifluoropropionamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-(1',1'-Dimethylethyl)-2-methoxy-2-phenyl-3,3,3-trifluoropropionamide

There total 2 articles about (S)-N-(1',1'-Dimethylethyl)-2-methoxy-2-phenyl-3,3,3-trifluoropropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-Mosher acid (17257-71-5,20445-31-2,56135-03-6,81655-41-6) → (S)-N-(1',1'-Dimethylethyl)-2-methoxy-2-phenyl-3,3,3-trifluoropropionamide (150723-33-4)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl chloride / benzene / Ambient temperature

2: CHCl₃ / 2 h / Ambient temperature

With oxalyl dichloride; In chloroform; benzene;

DOI:10.1021/jo00071a039

Reference yield:

(R)-methoxytrifluoromethylphenylacetyl chloride (20445-33-4,39637-99-5) + tert-butylamine (75-64-9) → (S)-N-(1',1'-Dimethylethyl)-2-methoxy-2-phenyl-3,3,3-trifluoropropionamide (150723-33-4)

Guidance literature:

In chloroform; for 2h; Yield given; Ambient temperature;

DOI:10.1021/jo00071a039

Reference yield:

(S)-N-(1',1'-Dimethylethyl)-2-methoxy-2-phenyl-3,3,3-trifluoropropionamide (150723-33-4) → 1-tert-butylamino-2-phenyl-propan-2-ol + 3-tert-butylamino-1,1,1-trifluoro-2-phenyl-propan-2-ol

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; Title compound not separated from byproducts;

DOI:10.1039/b200323f

upstream raw materials:

(R)-methoxytrifluoromethylphenylacetyl chloride

tert-butylamine

(S)-Mosher acid