2-Chloro-6-morpholino-4H-pyran-4-one

Base Information

Chemical Name:2-Chloro-6-morpholino-4H-pyran-4-one
CAS No.:119671-47-5
Molecular Formula:C9H10ClNO3
Molecular Weight:215.636
Hs Code.:
European Community (EC) Number:635-016-2
DSSTox Substance ID:DTXSID50424999
Nikkaji Number:J1.481.364K
Wikidata:Q82237746
Mol file:119671-47-5.mol

Synonyms:119671-47-5;2-Chloro-6-morpholino-4H-pyran-4-one;2-Chloro-6-morpholinopyran-4-one;2-chloro-6-morpholin-4-ylpyran-4-one;4H-Pyran-4-one, 2-chloro-6-(4-morpholinyl)-;SCHEMBL2763128;DTXSID50424999;QGZKNCBYDQXMQU-UHFFFAOYSA-N;AMY42323;MFCD28405027;2-Chloro-6-morpholin-4-yl-pyran-4-one;AS-65853;CS-0039098;2-Chloro-6-(4-morpholinyl)-4H-pyran-4-one;2-chloro-6-(morpholin-4-yl)-4H-pyran-4-one;A921817

Suppliers and Price of 2-Chloro-6-morpholino-4H-pyran-4-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Chloro-6-morpholinopyran-4-one(>90%)
1g
$ 540.00

Crysdot
2-Chloro-6-morpholino-4H-pyran-4-one 95+%
5g
$ 610.00

Alichem
2-Chloro-6-morpholino-4H-pyran-4-one
5g
$ 671.00

Alichem
2-Chloro-6-morpholino-4H-pyran-4-one
25g
$ 1083.88

AK Scientific
2-chloro-6-morpholin-4-ylpyran-4-one
5g
$ 1060.40

AK Scientific
2-chloro-6-morpholin-4-ylpyran-4-one
1g
$ 384.80

AK Scientific
2-chloro-6-morpholin-4-ylpyran-4-one
250mg
$ 216.80

AK Scientific
2-chloro-6-morpholin-4-ylpyran-4-one
100mg
$ 150.80

Total 10 raw suppliers

Chemical Property of 2-Chloro-6-morpholino-4H-pyran-4-one

Chemical Property:

Melting Point:100 - 103°C
Boiling Point:373.2±42.0 °C(Predicted)
PKA:0.05±0.20(Predicted)
PSA：42.68000
Density:1.39±0.1 g/cm3(Predicted)
LogP:1.19480
Storage Temp.:-20°C Freezer, Under inert atmosphere
Solubility.:Acetonitrile (Slightly), Chloroform (Slightly), DMSO (Slightly)
XLogP3:0.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:215.0349209
Heavy Atom Count:14
Complexity:305

Purity/Quality:

99%, ^*data from raw suppliers

2-Chloro-6-morpholinopyran-4-one(>90%) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1COCCN1C2=CC(=O)C=C(O2)Cl
Uses 2-Chloro-6-morpholinopyran-4-one is a compound being investigated as a DNA-dependent protein kinase inhibitor and Ataxia Telangiectasia Mutated kinase inhibitor.

Technology Process of 2-Chloro-6-morpholino-4H-pyran-4-one

There total 3 articles about 2-Chloro-6-morpholino-4H-pyran-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 85839-49-2
4,4-dichloro-1-(morpholin-4-yl)but-3-ene-1,2-dione

: 119671-47-5
6-chloro-2-(4-morpholin-4-yl)pyran-4-one

Guidance literature:: With perchloric acid; In 1,4-dioxane; at 90 ℃; for 1h;
DOI:10.1021/jm061121y

Reference yield:

: 81189-95-9
4-chloro-4-(2,2,2-trichloroethyl)-oxetan-2-one

: 119671-47-5
6-chloro-2-(4-morpholin-4-yl)pyran-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / NaHCO₃ / CH₂Cl₂ / 2.33 h / 15 °C

2: 75 percent / perchloric acid / dioxane / 1 h / 90 °C

With perchloric acid; sodium hydrogencarbonate; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm061121y