Chemical Property of 2-Morpholino-6-(thianthren-1-yl)-4H-pyran-4-one
Chemical Property:
- Vapor Pressure:1.1E-15mmHg at 25°C
- Refractive Index:1.714
- Boiling Point:628 °C at 760 mmHg
- PKA:0.33±0.20(Predicted)
- Flash Point:333.6 °C
- PSA：93.28000
- Density:1.419 g/cm3
- LogP:4.82420
- Storage Temp.:Desiccate at -20°C
- Solubility.:Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml)
- XLogP3:3.9
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:6
- Rotatable Bond Count:2
- Exact Mass:395.06498575
- Heavy Atom Count:27
- Complexity:643
- Purity/Quality:
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99%, *data from raw suppliers
KU-55933 ≥95% *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:C1COCCN1C2=CC(=O)C=C(O2)C3=C4C(=CC=C3)SC5=CC=CC=C5S4
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Description
Potent and selective ATM kinase inhibitor IC50s= 13, 2500, 9300, 16600, >100000 and >100000 nM for ATM, DNA-PK, mTOR, PI 3-kinase, PI 4-K and ATR respectively.1Decreases viability of MCF-7, A549 and HCT116 cells and decreases p21CIP1?levels?in vitro.2?Disruption of ATM signaling in primary A-T fibroblasts leads to dysregulation of ribonucleotide reductase and increase resistance to inhibitors of mitochondrial respiration and translation.3?Sensitizes radio-resistant cancer cells.4Provides neuroprotection against H2O2-induced cell damage.5
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Uses
A potent and specific ATM kinase inhibitor with an IC50 and a Ki of 13 nM and 2.2 nM, respectively. KU-55933 has been used as an ataxia-telangiectasia mutated (Atm) inhibitor.
