Tedizolid Impurity 3

Base Information

• Chemical Name: Tedizolid Impurity 3
• CAS No.: 1835340-19-6
• Molecular Formula: C₁₇H₁₆FN₆O₆P
• Molecular Weight: 450.323
• Mol file: 1835340-19-6.mol

Synonyms:

Chemical Property of Tedizolid Impurity 3

Chemical Property:

• Boiling Point: 725.6±70.0 °C(Predicted)
• PKA: 1.81±0.10(Predicted)
• Density: 1.75±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

ent-TedizolidPhosphate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: ent-Tedizolid Phosphate is an impurity of Tedizolid (T013750), an oral and i.v administered intracellular antibacterial drug.

Technology Process of Tedizolid Impurity 3

There total 26 articles about Tedizolid Impurity 3 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one (856866-72-3) → (R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridine-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate (1835340-19-6,856867-55-5)

Guidance literature:

With triethylamine; trichlorophosphate; In tetrahydrofuran; at 0 ℃; for 3h;

Reference yield: 96.0%

dibenzyl (R)-[3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-2-oxo-5-oxazolidinyl]methyl phosphoric acid → (R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridine-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate (1835340-19-6,856867-55-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; water; at 50 ℃; for 12h; under 760.051 Torr;

Reference yield: 80.3%

[(R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-2-oxo-5-oxazolidinyl]methyl disodium phosphate → (R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridine-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate (1835340-19-6,856867-55-5)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; water; for 0.25h; pH=3;

upstream raw materials:

(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one

2,5-dibromopyridine

2-Cyano-5-bromopyridine

5-bromo-2-(2-methyl-2H-tetrazol-5-yl)pyridine