Torezolid

Base Information

Chemical Name:Torezolid
CAS No.:856866-72-3
Molecular Formula:C17H15FN6O3
Molecular Weight:370.343
Hs Code.:29339900
European Community (EC) Number:815-370-6
UNII:97HLQ82NGL
DSSTox Substance ID:DTXSID10234975
Nikkaji Number:J3.050.870J
Wikipedia:Tedizolid
Wikidata:Q7825683
NCI Thesaurus Code:C84222
RXCUI:1540825
Metabolomics Workbench ID:154963
ChEMBL ID:CHEMBL1257051
Mol file:856866-72-3.mol

Synonyms:Torezolid

Suppliers and Price of Torezolid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Tedizolid
50mg
$ 1190.00

Medical Isotopes, Inc.
Tedizolid
5 mg
$ 650.00

Matrix Scientific
(R)-3-(3-Fluoro-4-(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one 95%
250mg
$ 444.00

Matrix Scientific
3-[3-Fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)-3-pyridinyl]phenyl]-5-(hydroxymethyl)-2-oxazolidinone 95%
100mg
$ 916.00

Matrix Scientific
3-[3-Fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)-3-pyridinyl]phenyl]-5-(hydroxymethyl)-2-oxazolidinone 95%
250mg
$ 1832.00

Matrix Scientific
(R)-3-(3-Fluoro-4-(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one 95%
1g
$ 1323.00

Labseeker
Torezolid 98
100g
$ 3566.00

DC Chemicals
Tedizolid >98%
250 mg
$ 800.00

DC Chemicals
Tedizolid >98%
100 mg
$ 450.00

Crysdot
Tedizolid 98+%
50mg
$ 432.00

Total 119 raw suppliers

Chemical Property of Torezolid

Chemical Property:

Melting Point:201 °C
Boiling Point:614.5±65.0 °C(Predicted)
PKA:14.05±0.10(Predicted)
PSA：106.26000
Density:1.57
LogP:1.46070
Storage Temp.:Refrigerator
Solubility.:DMSO (Slightly, Heated), Water (Slightly, Heated)
XLogP3:1.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:4
Exact Mass:370.11896652
Heavy Atom Count:27
Complexity:543

Purity/Quality:

99%, ^*data from raw suppliers

Tedizolid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Drug Classes:Antiinfective Agents
Canonical SMILES:CN1N=C(N=N1)C2=NC=C(C=C2)C3=C(C=C(C=C3)N4CC(OC4=O)CO)F
Isomeric SMILES:CN1N=C(N=N1)C2=NC=C(C=C2)C3=C(C=C(C=C3)N4C[C@@H](OC4=O)CO)F
Recent ClinicalTrials:Oral Antimicrobial Treatment vs. Outpatient Parenteral for Infective Endocarditis
Recent EU Clinical Trials:Oral antimicrobial treatment vs. outpatient parenteral for infective
Indications Tedizolid phosphate is an oxazolidinone compound used in the treatment of acute bacterial skin and skin structure infections caused by the following gram-positive bacteria-sensitive strains: Staphylococcus aureus (including Methicillin-resistant and methicillin-susceptible strains), pyogenic streptococci, Streptococcus lactis, Streptococcus angustifolia (including Angina, Streptococcus intermedius and Streptococcus constellation), and Enterococcus faecalis.

Technology Process of Torezolid

There total 25 articles about Torezolid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: C₂₃H₂₉FN₆O₃Si

: 856866-72-3
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one

Guidance literature:: With cesium fluoride; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield: 95.0%

: 1220910-89-3
3-fluoro-4-(6-(2-methyl-2H-tetrazole-5-yl)pyridin-3-yl)phenyl-carbamic acid benzylester

: 856866-72-3
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one

Guidance literature:: With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; tert.-butyl lithium; (R)-glycidyl butyrate; In tetrahydrofuran; at 0 - 30 ℃; for 15h; Reagent/catalyst; Large scale;

Reference yield: 86.7%

: 1220910-89-3
3-fluoro-4-(6-(2-methyl-2H-tetrazole-5-yl)pyridin-3-yl)phenyl-carbamic acid benzylester

: 60456-26-0
(R)-glycidyl butyrate

: 856866-72-3
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one

Guidance literature:: 3-fluoro-4-(6-(2-methyl-2H-tetrazole-5-yl)pyridin-3-yl)phenyl-carbamic acid benzylester; With potassium tert-butylate; lithium tert-butoxide; In tetrahydrofuran; acetonitrile; at 25 ℃; for 2h; Inert atmosphere;

(R)-glycidyl butyrate; In tetrahydrofuran; acetonitrile; for 3h;