Butanoic acid, 3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4-(hydroxymethoxyphosphinyl)-, methyl ester, (S)-

Base Information

Chemical Name:Butanoic acid, 3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4-(hydroxymethoxyphosphinyl)-, methyl ester, (S)-
CAS No.:119899-81-9
Molecular Formula:C22H31O6PSi
Molecular Weight:450.544
Hs Code.:

Synonyms:

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Chemical Property of Butanoic acid, 3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4-(hydroxymethoxyphosphinyl)-, methyl ester, (S)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Butanoic acid, 3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4-(hydroxymethoxyphosphinyl)-, methyl ester, (S)-

There total 5 articles about Butanoic acid, 3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4-(hydroxymethoxyphosphinyl)-, methyl ester, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 88759-56-2
(S)-bromo-3-hydroxybutyric acid methyl ester

: 119899-81-9
(S)-4-(hydroxymethoxyphosphinyl)-3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>butanoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: imidazole, DMAP / dimethylformamide / Ambient temperature

2: sodium iodide / butan-2-one / 5 h / Heating

3: 75 percent / 16.5 h / 155 °C

4: bis(trimethylsilyl)trifluoroacetamide (BSTFA), trimethylsilyl bromide (TMSBr) / CH₂Cl₂ / 20 h / Ambient temperature

5: dicyclohexylcarbodiimide (DCC), pyridine / 20 h / Ambient temperature

With pyridine; 1H-imidazole; dmap; bis(trimethylsilyl)trifluoroacetamide; trimethylsilyl bromide; dicyclohexyl-carbodiimide; sodium iodide; In dichloromethane; N,N-dimethyl-formamide; butanone;
DOI:10.1021/jm00113a019

Reference yield:

: 119673-72-2
(S)-4-iodo-3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>butanoic acid methyl ester

: 119899-81-9
(S)-4-(hydroxymethoxyphosphinyl)-3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>butanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / 16.5 h / 155 °C

2: bis(trimethylsilyl)trifluoroacetamide (BSTFA), trimethylsilyl bromide (TMSBr) / CH₂Cl₂ / 20 h / Ambient temperature

3: dicyclohexylcarbodiimide (DCC), pyridine / 20 h / Ambient temperature

With pyridine; bis(trimethylsilyl)trifluoroacetamide; trimethylsilyl bromide; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1021/jm00113a019

Reference yield:

: 119673-71-1
Methyl 3S-((t-butyl)diphenylsilyloxy)-4-bromo butanoate

: 119899-81-9
(S)-4-(hydroxymethoxyphosphinyl)-3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>butanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: sodium iodide / butan-2-one / 5 h / Heating

2: 75 percent / 16.5 h / 155 °C

3: bis(trimethylsilyl)trifluoroacetamide (BSTFA), trimethylsilyl bromide (TMSBr) / CH₂Cl₂ / 20 h / Ambient temperature

4: dicyclohexylcarbodiimide (DCC), pyridine / 20 h / Ambient temperature

With pyridine; bis(trimethylsilyl)trifluoroacetamide; trimethylsilyl bromide; dicyclohexyl-carbodiimide; sodium iodide; In dichloromethane; butanone;
DOI:10.1021/jm00113a019