(S)-4-({2-[4-(4-Fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-yl]-ethyl}-methoxy-phosphinoyl)-3-hydroxy-butyric acid methyl ester

Base Information

Chemical Name:(S)-4-({2-[4-(4-Fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-yl]-ethyl}-methoxy-phosphinoyl)-3-hydroxy-butyric acid methyl ester
CAS No.:129122-54-9
Molecular Formula:C₂₈H₃₃FNO₅P
Molecular Weight:513.546
Hs Code.:

Synonyms:(S)-4-({2-[4-(4-Fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-yl]-ethyl}-methoxy-phosphinoyl)-3-hydroxy-butyric acid methyl ester

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Chemical Property of (S)-4-({2-[4-(4-Fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-yl]-ethyl}-methoxy-phosphinoyl)-3-hydroxy-butyric acid methyl ester

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Technology Process of (S)-4-({2-[4-(4-Fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-yl]-ethyl}-methoxy-phosphinoyl)-3-hydroxy-butyric acid methyl ester

There total 17 articles about (S)-4-({2-[4-(4-Fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-yl]-ethyl}-methoxy-phosphinoyl)-3-hydroxy-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 129122-44-7
(S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[4-(4-fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester

: 129122-54-9
(S)-4-({2-[4-(4-Fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-yl]-ethyl}-methoxy-phosphinoyl)-3-hydroxy-butyric acid methyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 72h; under 2585.7 Torr;
DOI:10.1021/jm00113a019

Reference yield:

: 1608-51-1
4-fluorochalcone

: 129122-54-9
(S)-4-({2-[4-(4-Fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-yl]-ethyl}-methoxy-phosphinoyl)-3-hydroxy-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: EtONa / ethanol / 4.5 h / Ambient temperature

2: NH₄OAc, Cu(OAc)2 / acetic acid / 24 h / Heating

3: LiAlH₄ / tetrahydrofuran / 6 h / Ambient temperature

4: 87 percent / Dess-Martin periodinane / CH₂Cl₂ / 0.5 h / Ambient temperature

5: triphenylphosphine / CH₂Cl₂ / 0.42 h / Ambient temperature

6: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

7: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 20 min, 2.) THF, hexane, -78 deg C, 30 min

8: H₂ / 10percent Pd/C / methanol / 72 h / 2585.7 Torr

With lithium aluminium tetrahydride; n-butyllithium; copper diacetate; ammonium acetate; hydrogen; sodium ethanolate; Dess-Martin periodane; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; acetic acid;
DOI:10.1021/jm00113a019

Reference yield:

: 122253-00-3
4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinemethanol

: 129122-54-9
(S)-4-({2-[4-(4-Fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-yl]-ethyl}-methoxy-phosphinoyl)-3-hydroxy-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 87 percent / Dess-Martin periodinane / CH₂Cl₂ / 0.5 h / Ambient temperature

2: triphenylphosphine / CH₂Cl₂ / 0.42 h / Ambient temperature

3: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

4: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 20 min, 2.) THF, hexane, -78 deg C, 30 min

5: H₂ / 10percent Pd/C / methanol / 72 h / 2585.7 Torr

With n-butyllithium; hydrogen; Dess-Martin periodane; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1021/jm00113a019