2-(2-chloro-4-(2H-tetrazol-5-yl)phenyl)quinolin-6-ol

Base Information

Chemical Name:2-(2-chloro-4-(2H-tetrazol-5-yl)phenyl)quinolin-6-ol
CAS No.:1371587-66-4
Molecular Formula:C₁₆H₁₀ClN₅O
Molecular Weight:323.741
Hs Code.:

Synonyms:

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Chemical Property of 2-(2-chloro-4-(2H-tetrazol-5-yl)phenyl)quinolin-6-ol

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Technology Process of 2-(2-chloro-4-(2H-tetrazol-5-yl)phenyl)quinolin-6-ol

There total 8 articles about 2-(2-chloro-4-(2H-tetrazol-5-yl)phenyl)quinolin-6-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6563-13-9
6-methoxyquinoline N-oxide

: 1371587-66-4
2-(2-chloro-4-(2H-tetrazol-5-yl)phenyl)quinolin-6-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: acetic anhydride / 2 h / Reflux

2.1: trichlorophosphate / 2 h / Reflux

3.1: potassium carbonate; 2-(2-methoxyethoxy)ethyl alcohol / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water / 3 h / 110 °C / Inert atmosphere

4.1: aluminum (III) chloride / dichloromethane / Reflux

5.1: thionyl chloride / 1 h / Reflux

5.2: 1 h / 30 °C

5.3: pH 6

6.1: triethylamine; trifluoroacetic acid / dichloromethane / 30 °C

7.1: sodium azide; 2-(2-methoxyethoxy)ethyl alcohol; lithium chloride / 4 h / Reflux

With aluminum (III) chloride; thionyl chloride; sodium azide; 2-(2-methoxyethoxy)ethyl alcohol; acetic anhydride; potassium carbonate; triethylamine; trifluoroacetic acid; lithium chloride; trichlorophosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In dichloromethane; water;

Reference yield:

: 5263-87-6
6-methoxy quinoline

: 1371587-66-4
2-(2-chloro-4-(2H-tetrazol-5-yl)phenyl)quinolin-6-ol

Guidance literature:: Multi-step reaction with 8 steps

1.1: dihydrogen peroxide / water; acetic acid / 21 h / 70 °C

1.2: pH 8 - 9

2.1: acetic anhydride / 2 h / Reflux

3.1: trichlorophosphate / 2 h / Reflux

4.1: potassium carbonate; 2-(2-methoxyethoxy)ethyl alcohol / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water / 3 h / 110 °C / Inert atmosphere

5.1: aluminum (III) chloride / dichloromethane / Reflux

6.1: thionyl chloride / 1 h / Reflux

6.2: 1 h / 30 °C

6.3: pH 6

7.1: triethylamine; trifluoroacetic acid / dichloromethane / 30 °C

8.1: sodium azide; 2-(2-methoxyethoxy)ethyl alcohol; lithium chloride / 4 h / Reflux

With aluminum (III) chloride; thionyl chloride; sodium azide; 2-(2-methoxyethoxy)ethyl alcohol; dihydrogen peroxide; acetic anhydride; potassium carbonate; triethylamine; trifluoroacetic acid; lithium chloride; trichlorophosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In dichloromethane; water; acetic acid;

Reference yield:

: 13676-02-3
2-chloro-6-methoxyquinoline

: 1371587-66-4
2-(2-chloro-4-(2H-tetrazol-5-yl)phenyl)quinolin-6-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate; 2-(2-methoxyethoxy)ethyl alcohol / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water / 3 h / 110 °C / Inert atmosphere

2.1: aluminum (III) chloride / dichloromethane / Reflux

3.1: thionyl chloride / 1 h / Reflux

3.2: 1 h / 30 °C

3.3: pH 6

4.1: triethylamine; trifluoroacetic acid / dichloromethane / 30 °C

5.1: sodium azide; 2-(2-methoxyethoxy)ethyl alcohol; lithium chloride / 4 h / Reflux

With aluminum (III) chloride; thionyl chloride; sodium azide; 2-(2-methoxyethoxy)ethyl alcohol; potassium carbonate; triethylamine; trifluoroacetic acid; lithium chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In dichloromethane; water;