N₁-(4-chlorophenyl)-N₃-{4-[2-hydroxy-3-(5-carbethoxy-6-methyl-2-thio-4-(3-nitrophenyl)-1,2,3,4-tetrahydropyrimidin-1-yl)propoxy]benzylidene}thiourea

Base Information

• Chemical Name: N₁-(4-chlorophenyl)-N₃-{4-[2-hydroxy-3-(5-carbethoxy-6-methyl-2-thio-4-(3-nitrophenyl)-1,2,3,4-tetrahydropyrimidin-1-yl)propoxy]benzylidene}thiourea
• CAS No.: 1229661-67-9
• Molecular Formula: C₃₁H₃₀ClN₅O₆S₂
• Molecular Weight: 668.194

Synonyms:

Chemical Property of N₁-(4-chlorophenyl)-N₃-{4-[2-hydroxy-3-(5-carbethoxy-6-methyl-2-thio-4-(3-nitrophenyl)-1,2,3,4-tetrahydropyrimidin-1-yl)propoxy]benzylidene}thiourea

Chemical Property:

Purity/Quality:

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Useful:

Technology Process of N₁-(4-chlorophenyl)-N₃-{4-[2-hydroxy-3-(5-carbethoxy-6-methyl-2-thio-4-(3-nitrophenyl)-1,2,3,4-tetrahydropyrimidin-1-yl)propoxy]benzylidene}thiourea

There total 5 articles about N₁-(4-chlorophenyl)-N₃-{4-[2-hydroxy-3-(5-carbethoxy-6-methyl-2-thio-4-(3-nitrophenyl)-1,2,3,4-tetrahydropyrimidin-1-yl)propoxy]benzylidene}thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-aniline (106-47-8) → N1-(4-chlorophenyl)-N3-{4-[2-hydroxy-3-(5-carbethoxy-6-methyl-2-thio-4-(3-nitrophenyl)-1,2,3,4-tetrahydropyrimidin-1-yl)propoxy]benzylidene}thiourea (1229661-67-9)

Guidance literature:

Multi-step reaction with 4 steps

1: benzoyl chloride / acetone

2: dicyclohexyl-carbodiimide / tetrahydrofuran; ethanol; water / 2 h / Reflux

3: sodium carbonate / acetone / 37 h / Reflux

4: acetone / 15 h / Reflux

With sodium carbonate; benzoyl chloride; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol; water; acetone;

DOI:10.1007/s00044-010-9374-6

Reference yield:

C14H11ClN2OS (1229661-71-5) → N1-(4-chlorophenyl)-N3-{4-[2-hydroxy-3-(5-carbethoxy-6-methyl-2-thio-4-(3-nitrophenyl)-1,2,3,4-tetrahydropyrimidin-1-yl)propoxy]benzylidene}thiourea (1229661-67-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate / acetone / 37 h / Reflux

2: acetone / 15 h / Reflux

With sodium carbonate; In acetone;

DOI:10.1007/s00044-010-9374-6

Reference yield:

N-(4-chlorophenyl)thiourea (3696-23-9) → N1-(4-chlorophenyl)-N3-{4-[2-hydroxy-3-(5-carbethoxy-6-methyl-2-thio-4-(3-nitrophenyl)-1,2,3,4-tetrahydropyrimidin-1-yl)propoxy]benzylidene}thiourea (1229661-67-9)

Guidance literature:

Multi-step reaction with 3 steps

1: dicyclohexyl-carbodiimide / tetrahydrofuran; ethanol; water / 2 h / Reflux

2: sodium carbonate / acetone / 37 h / Reflux

3: acetone / 15 h / Reflux

With sodium carbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol; water; acetone;

DOI:10.1007/s00044-010-9374-6

upstream raw materials:

C₁₄H₁₁ClN₂OS

C₁₇H₁₅ClN₂O₂S

ethyl 6-methyl-4-(3-nitrophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-carboxylate

ethyl acetoacetate

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