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1268729-57-2

methyl N2-[(tert-butoxy)carbonyl]-N6-[(phenylmethoxy)carbonyl]-L-lysyl-N-methyl-D-valyl-N-methyl-D-alaninate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • methyl N2-[(tert-butoxy)carbonyl]-N6-[(phenylmethoxy)carbonyl]-L-lysyl-N-methyl-D-valyl-N-methyl-D-alaninate

    Cas No: 1268729-57-2

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  • 1268729-57-2 Structure

  • Basic information

    1. Product Name: methyl N2-[(tert-butoxy)carbonyl]-N6-[(phenylmethoxy)carbonyl]-L-lysyl-N-methyl-D-valyl-N-methyl-D-alaninate
    2. Synonyms: methyl N2-[(tert-butoxy)carbonyl]-N6-[(phenylmethoxy)carbonyl]-L-lysyl-N-methyl-D-valyl-N-methyl-D-alaninate
    3. CAS NO:1268729-57-2
    4. Molecular Formula:
    5. Molecular Weight: 592.733
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1268729-57-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: methyl N2-[(tert-butoxy)carbonyl]-N6-[(phenylmethoxy)carbonyl]-L-lysyl-N-methyl-D-valyl-N-methyl-D-alaninate(CAS DataBase Reference)
    10. NIST Chemistry Reference: methyl N2-[(tert-butoxy)carbonyl]-N6-[(phenylmethoxy)carbonyl]-L-lysyl-N-methyl-D-valyl-N-methyl-D-alaninate(1268729-57-2)
    11. EPA Substance Registry System: methyl N2-[(tert-butoxy)carbonyl]-N6-[(phenylmethoxy)carbonyl]-L-lysyl-N-methyl-D-valyl-N-methyl-D-alaninate(1268729-57-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1268729-57-2(Hazardous Substances Data)

1268729-57-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1268729-57-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,6,8,7,2 and 9 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1268729-57:
(9*1)+(8*2)+(7*6)+(6*8)+(5*7)+(4*2)+(3*9)+(2*5)+(1*7)=202
202 % 10 = 2
So 1268729-57-2 is a valid CAS Registry Number.

1268729-57-2Relevant articles and documents

Total synthesis, absolute configuration, and biological activity of xyloallenoide A

Wang, San-Yong,Xu, Zhong-Liang,Wang, Hui,Li, Chun-Rong,Fu, Li-Wu,Pang, Ji-Yan,Li, Jing,She, Zhi-Gang,Lin, Yong-Cheng

, p. 973 - 982 (2012/08/08)

The novel natural product xyloallenoide A, isolated from the marine mangrove endophytic fungus from the South China Sea, and its diastereoisomer xyloallenoide A1, which contain N-methyl-substituted amino acids, were synthesized. The absolute configurations of the amino acid units of xyloallenoide A were finally confirmed to be L-Lys, Me-D-Val, and Me-L-Ala. This report represents a practical and attractive alternative for the synthesis of N-methyl-substituted cyclotripeptides. In the preliminary bioassay, synthetic xyloallenoide A showed marginal activities against KB (IC50=9.6 mm) and KBv200 cells (IC50=10.3 μm), and xyloallenoide A1 was inactive against KB and KBv200 cells.

Marine cyclotripeptide X-13 promotes angiogenesis in zebrafish and human endothelial cells via PI3K/Akt/eNOS signaling pathways

Lu, Xi-Lin,Xu, Zhong-Liang,Yao, Xiao-Li,Su, Feng-Juan,Ye, Cheng-Hui,Li, Jing,Lin, Yong-Cheng,Wang, Guang-Lei,Zeng, Jin-Sheng,Huang, Ru-Xun,Ou, Jing-Song,Sun, Hong-Shuo,Wang, Li-Ping,Pang, Ji-Yan,Pei, Zhong

, p. 1307 - 1320 (2012/08/08)

Cyclotripeptide X-13 is a core of novel marine compound xyloallenoide A isolated from mangrove fungus Xylaria sp. (no. 2508). We found that X-13 dose-dependently induced angiogenesis in zebrafish embryos and in human endothelial cells, which was accompanied by increased phosphorylation of eNOS and Akt and NO release. Inhibition of PI3K/Akt/eNOS by LY294002 or L-NAME suppressed X-13-induced angiogenesis. The present work demonstrates that X-13 promotes angiogenesis via PI3K/Akt/eNOS pathways.

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