(R)-baclofen hydrochloride

Base Information

• Chemical Name: (R)-baclofen hydrochloride
• CAS No.: 1375081-89-2
• Molecular Formula: C₉H₁₀ClNO₂*ClH
• Molecular Weight: 236.098
• Mol file: 1375081-89-2.mol

Synonyms:

Chemical Property of (R)-baclofen hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-baclofen hydrochloride

There total 6 articles about (R)-baclofen hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(R)-(-)-4-(4-chlorophenyl)pyrrolidin-2-one (123632-35-9) → (R)-baclofen hydrochloride (1375081-89-2)

Guidance literature:

With hydrogenchloride; water; at 100 ℃; for 12h;

DOI:10.1055/s-0030-1260187

Reference yield:

(R)-3-(4-chlorophenyl)-3-hydroxy-1-[(S)-5-isopropyl-3-phenyl-2-thioxoimidazolidin-1-yl]propan-1-one (1350820-23-3) → (R)-baclofen hydrochloride (1375081-89-2)

Guidance literature:

Multi-step reaction with 5 steps

1: potassium carbonate / 2 h / 20 °C

2: pyridine; phosphorus tribromide / diethyl ether / 14 h / -20 - 20 °C

3: tetrabutyl ammonium fluoride / acetonitrile / Reflux

4: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol / 1 h / 20 °C / Reflux

5: hydrogenchloride; water / 12 h / 100 °C

With pyridine; hydrogenchloride; sodium tetrahydroborate; nickel(II) chloride hexahydrate; tetrabutyl ammonium fluoride; water; phosphorus tribromide; potassium carbonate; In methanol; diethyl ether; acetonitrile;

DOI:10.1055/s-0030-1260187

Reference yield:

4-chlorobenzaldehyde (104-88-1) → (R)-baclofen hydrochloride (1375081-89-2)

Guidance literature:

Multi-step reaction with 6 steps

1.1: titanium tetrachloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 1.17 h / -78 °C / Inert atmosphere

1.2: 0.5 h / -78 °C / Inert atmosphere

2.1: potassium carbonate / 2 h / 20 °C

3.1: pyridine; phosphorus tribromide / diethyl ether / 14 h / -20 - 20 °C

4.1: tetrabutyl ammonium fluoride / acetonitrile / Reflux

5.1: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol / 1 h / 20 °C / Reflux

6.1: hydrogenchloride; water / 12 h / 100 °C

With pyridine; hydrogenchloride; sodium tetrahydroborate; nickel(II) chloride hexahydrate; tetrabutyl ammonium fluoride; water; phosphorus tribromide; titanium tetrachloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; diethyl ether; dichloromethane; acetonitrile; 1.1: Aldol condensation / 1.2: Aldol condensation;

DOI:10.1055/s-0030-1260187

upstream raw materials:

(R)-3-(4-chlorophenyl)-3-hydroxy-1-[(S)-5-isopropyl-3-phenyl-2-thioxoimidazolidin-1-yl]propan-1-one

4-chlorobenzaldehyde

(R)-(-)-4-(4-chlorophenyl)pyrrolidin-2-one

(R)-3-hydroxy-3-(4-chlorophenyl)-propionic acid ethyl ester