Clopidogrel EP IMpurity D

Base Information

Chemical Name:Clopidogrel EP IMpurity D
CAS No.:1421283-60-4
Molecular Formula:C₂₄H₂₁Cl₂NO₄S
Molecular Weight:490.407
Hs Code.:
Mol file:1421283-60-4.mol

Synonyms:

Suppliers and Price of Clopidogrel EP IMpurity D

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
ClopidogrelCarboxylicAcid[Methyl(R)-o-chloromandelate]Ester
10mg
$ 1695.00

Total 12 raw suppliers

Chemical Property of Clopidogrel EP IMpurity D

Chemical Property:

Boiling Point:593.2±50.0 °C(Predicted)
PKA:4.18±0.20(Predicted)
Density:1.384±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

ClopidogrelCarboxylicAcid[Methyl(R)-o-chloromandelate]Ester ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Clopidogrel Carboxylic Acid [Methyl (R)-o-chloromandelate] Ester is an impurity of Clopidogrel (C587250), an antithrombotic agent.

Technology Process of Clopidogrel EP IMpurity D

There total 4 articles about Clopidogrel EP IMpurity D which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: C₂₃H₂₁Cl₂NO₄S

: 1421283-60-4
(2R)-(2-chlorophenyl) [(2S)-(2-chlorophenyl) [4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl]acetoxyl]methyl acetate

Guidance literature:: C₂₃H₂₁Cl₂NO₄S; With hydrogenchloride; In water; acetone; at 2.5 ℃; for 2h;

formaldehyd; at 57.5 ℃; for 3h;

Reference yield:

: 141315-50-6
(S)-2-amino-(2-chlorophenyl)ethanoic acid

: 1421283-60-4
(2R)-(2-chlorophenyl) [(2S)-(2-chlorophenyl) [4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl]acetoxyl]methyl acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate / dichloromethane / 2.5 - 20 °C

2.1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 3 h / 20 °C

3.1: trimethylsilyl iodide / acetonitrile / 20 °C

4.1: triethylamine / acetonitrile / Reflux

5.1: hydrogenchloride / acetone; water / 2 h / 2.5 °C

5.2: 3 h / 57.5 °C

With hydrogenchloride; dmap; trimethylsilyl iodide; sodium hydrogencarbonate; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; water; acetone; acetonitrile;

Reference yield:

: benzyloxycarbonyl dextro-o-chlorophenylglycine

: 1421283-60-4
(2R)-(2-chlorophenyl) [(2S)-(2-chlorophenyl) [4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl]acetoxyl]methyl acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 3 h / 20 °C

2.1: trimethylsilyl iodide / acetonitrile / 20 °C

3.1: triethylamine / acetonitrile / Reflux

4.1: hydrogenchloride / acetone; water / 2 h / 2.5 °C

4.2: 3 h / 57.5 °C

With hydrogenchloride; dmap; trimethylsilyl iodide; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; water; acetone; acetonitrile;