oclacitinib maleate

Base Information

• Chemical Name: oclacitinib maleate
• CAS No.: 1640292-55-2
• Molecular Formula: C₄H₄O₄*C₁₅H₂₃N₅O₂S
• Molecular Weight: 453.519
• Mol file: 1640292-55-2.mol

Synonyms:

Chemical Property of oclacitinib maleate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

OclacitinibMaleate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Oclacitinib Maleate is a novel Janus kinase (JAK) inhibitor with activity against cytokines involved in allergy (1,2).

Technology Process of oclacitinib maleate

There total 25 articles about oclacitinib maleate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.6%

Oclacitinib + maleic acid (110-16-7,26099-09-2) → N-methyl-1-{trans-4-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexyl}methanesulfonamide maleate (1208319-27-0,1640292-55-2)

Guidance literature:

With pyrographite; In ethanol; at 78 - 80 ℃;

Reference yield: 95.5%

N-methyl-1-{trans-4-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexyl}methanesulfonamide + (2E)-but-2-enedioic acid (110-17-8,26099-09-2) → oclacitinib maleate (1208319-27-0,1640292-55-2)

Guidance literature:

With pyrographite; In ethanol; at 78 - 80 ℃;

Reference yield:

N-methyl-1-{trans-4-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexyl}methanesulfonamide + maleic acid (110-16-7,26099-09-2) → N-methyl-1-{trans-4-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexyl}methanesulfonamide maleate (1208319-27-0,1640292-55-2)

Guidance literature:

In water; butan-1-ol; at 20 ℃; for 18h;

upstream raw materials:

maleic acid

trans-4-((methylamino)cyclohexyl)methanesulfonic acid

1-bromomethyl-4-bromobenzene

cyclohexanedione monoethylene ketal

Refernces

• 1、 -. "SOLID STATE FORMS OF OCLACITINIB MALEATE". Page/Page column 13-14. . Retrieved 2020/08/22.
• 2、 -. "PROCESS FOR PREPARING 7H-PYRROLO[2,3-D]PYRIMIDINE COMPOUNDS". . . Retrieved 2017/09/02.