3-Methyl-2-[(3R,4R)-2-oxo-3-(2-oxo-3-phenyl-propyl)-4-(2-phenoxy-acetylsulfanyl)-azetidin-1-yl]-but-2-enoic acid 2,2,2-trichloro-ethyl ester

Base Information

Chemical Name:3-Methyl-2-[(3R,4R)-2-oxo-3-(2-oxo-3-phenyl-propyl)-4-(2-phenoxy-acetylsulfanyl)-azetidin-1-yl]-but-2-enoic acid 2,2,2-trichloro-ethyl ester
CAS No.:164033-57-2
Molecular Formula:C₂₇H₂₆Cl₃NO₆S
Molecular Weight:598.932
Hs Code.:

3-Methyl-2-[(3R,4R)-2-oxo-3-(2-oxo-3-phenyl-propyl)-4-(2-phenoxy-acetylsulfanyl)-azetidin-1-yl]-but-2-enoic acid 2,2,2-trichloro-ethyl ester

Synonyms:

Suppliers and Price of 3-Methyl-2-[(3R,4R)-2-oxo-3-(2-oxo-3-phenyl-propyl)-4-(2-phenoxy-acetylsulfanyl)-azetidin-1-yl]-but-2-enoic acid 2,2,2-trichloro-ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-Methyl-2-[(3R,4R)-2-oxo-3-(2-oxo-3-phenyl-propyl)-4-(2-phenoxy-acetylsulfanyl)-azetidin-1-yl]-but-2-enoic acid 2,2,2-trichloro-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-Methyl-2-[(3R,4R)-2-oxo-3-(2-oxo-3-phenyl-propyl)-4-(2-phenoxy-acetylsulfanyl)-azetidin-1-yl]-but-2-enoic acid 2,2,2-trichloro-ethyl ester

There total 5 articles about 3-Methyl-2-[(3R,4R)-2-oxo-3-(2-oxo-3-phenyl-propyl)-4-(2-phenoxy-acetylsulfanyl)-azetidin-1-yl]-but-2-enoic acid 2,2,2-trichloro-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 63784-21-4
6-oxo-penicillanic acid 2,2,2-trichloro-ethyl ester

: 164033-57-2
3-Methyl-2-[(3R,4R)-2-oxo-3-(2-oxo-3-phenyl-propyl)-4-(2-phenoxy-acetylsulfanyl)-azetidin-1-yl]-but-2-enoic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: CH₂Cl₂ / 0 °C

2: H₂ / (Ph₃P)3RhCl / CH₂Cl₂; ethyl acetate

3: PhHgCl, DBU / acetonitrile / Ambient temperature

4: acetonitrile

With hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; phenylmercury(II) chloride; Wilkinson's catalyst; In dichloromethane; ethyl acetate; acetonitrile;
DOI:10.7164/antibiotics.48.399

Reference yield:

: 19474-18-1
6β-aminopenicillanic acid 2,2,2-trichloroethyl ester

: 164033-57-2
3-Methyl-2-[(3R,4R)-2-oxo-3-(2-oxo-3-phenyl-propyl)-4-(2-phenoxy-acetylsulfanyl)-azetidin-1-yl]-but-2-enoic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaNO₂, 2.) O₃ / 1.) CH₂Cl₂, 2.) CH₂Cl₂, -10 deg C

2: CH₂Cl₂ / 0 °C

3: H₂ / (Ph₃P)3RhCl / CH₂Cl₂; ethyl acetate

4: PhHgCl, DBU / acetonitrile / Ambient temperature

5: acetonitrile

With hydrogen; ozone; 1,8-diazabicyclo[5.4.0]undec-7-ene; phenylmercury(II) chloride; sodium nitrite; Wilkinson's catalyst; In dichloromethane; ethyl acetate; acetonitrile;
DOI:10.7164/antibiotics.48.399

Reference yield:

: (2S,5R)-3,3-Dimethyl-7-oxo-6-[2-oxo-3-phenyl-prop-(Z)-ylidene]-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 2,2,2-trichloro-ethyl ester

: 164033-57-2
3-Methyl-2-[(3R,4R)-2-oxo-3-(2-oxo-3-phenyl-propyl)-4-(2-phenoxy-acetylsulfanyl)-azetidin-1-yl]-but-2-enoic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / (Ph₃P)3RhCl / CH₂Cl₂; ethyl acetate

2: PhHgCl, DBU / acetonitrile / Ambient temperature

3: acetonitrile

With hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; phenylmercury(II) chloride; Wilkinson's catalyst; In dichloromethane; ethyl acetate; acetonitrile;
DOI:10.7164/antibiotics.48.399