5,6-dibenzyloxy-2-formyl-2,3-dihydrobenzofuran

Base Information

• Chemical Name: 5,6-dibenzyloxy-2-formyl-2,3-dihydrobenzofuran
• CAS No.: 157259-34-2
• Molecular Formula: C₂₃H₂₀O₄
• Molecular Weight: 360.409
• Mol file: 157259-34-2.mol

Synonyms:

Chemical Property of 5,6-dibenzyloxy-2-formyl-2,3-dihydrobenzofuran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5,6-dibenzyloxy-2-formyl-2,3-dihydrobenzofuran

There total 5 articles about 5,6-dibenzyloxy-2-formyl-2,3-dihydrobenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4-dibenzyloxybenzaldehyde (5447-02-9) → 5,6-dibenzyloxy-2-formyl-2,3-dihydrobenzofuran (157259-34-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) m-chloroperbenzoic acid; 2.) 15percent NaOH / 1.) AcOEt, r.t.; 2.) THF, r.t., 30 min

2: 72 percent / H₂O; tetrahydrofuran / 2 h / Ambient temperature

3: 59.3 percent / potassium carbonate / dimethylformamide / 4 h / 60 - 70 °C

4: 94.3 percent / lithium aluminum hydride / tetrahydrofuran / 0.5 h / 0 °C

5: 61.8 percent / N,N'-dicyclohexylcarbodiimide, 1M H₃PO₄ / dimethylsulfoxide / 3 h / Ambient temperature

With sodium hydroxide; lithium aluminium tetrahydride; phosphoric acid; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

3,4-dibenzyloxyphenol (27688-86-4) → 5,6-dibenzyloxy-2-formyl-2,3-dihydrobenzofuran (157259-34-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 72 percent / H₂O; tetrahydrofuran / 2 h / Ambient temperature

2: 59.3 percent / potassium carbonate / dimethylformamide / 4 h / 60 - 70 °C

3: 94.3 percent / lithium aluminum hydride / tetrahydrofuran / 0.5 h / 0 °C

4: 61.8 percent / N,N'-dicyclohexylcarbodiimide, 1M H₃PO₄ / dimethylsulfoxide / 3 h / Ambient temperature

With lithium aluminium tetrahydride; phosphoric acid; potassium carbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

benzyl bromide (100-39-0) → 5,6-dibenzyloxy-2-formyl-2,3-dihydrobenzofuran (157259-34-2)

Guidance literature:

Multi-step reaction with 6 steps

1: 97.4 percent / potassium carbonate / acetone / 6 h / 80 °C

2: 1.) m-chloroperbenzoic acid; 2.) 15percent NaOH / 1.) AcOEt, r.t.; 2.) THF, r.t., 30 min

3: 72 percent / H₂O; tetrahydrofuran / 2 h / Ambient temperature

4: 59.3 percent / potassium carbonate / dimethylformamide / 4 h / 60 - 70 °C

5: 94.3 percent / lithium aluminum hydride / tetrahydrofuran / 0.5 h / 0 °C

6: 61.8 percent / N,N'-dicyclohexylcarbodiimide, 1M H₃PO₄ / dimethylsulfoxide / 3 h / Ambient temperature

With sodium hydroxide; lithium aluminium tetrahydride; phosphoric acid; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;

upstream raw materials:

3,4-dibenzyloxybenzaldehyde

3,4-dibenzyloxyphenol

benzyl bromide

4,5-dibenzyloxy-2-dimethylaminomethylphenol