(4-Cyclohexylamino-1-ethyl-1,2,3,4-tetrahydro-quinolin-8-yl)-methanol

Base Information

Chemical Name:(4-Cyclohexylamino-1-ethyl-1,2,3,4-tetrahydro-quinolin-8-yl)-methanol
CAS No.:130020-38-1
Molecular Formula:C₁₈H₂₈N₂O
Molecular Weight:288.433
Hs Code.:

Synonyms:

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Chemical Property of (4-Cyclohexylamino-1-ethyl-1,2,3,4-tetrahydro-quinolin-8-yl)-methanol

Chemical Property:

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Technology Process of (4-Cyclohexylamino-1-ethyl-1,2,3,4-tetrahydro-quinolin-8-yl)-methanol

There total 10 articles about (4-Cyclohexylamino-1-ethyl-1,2,3,4-tetrahydro-quinolin-8-yl)-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: {4-[(E)-Cyclohexylimino]-1-ethyl-1,2,3,4-tetrahydro-quinolin-8-yl}-methanol

: 130020-38-1
(4-Cyclohexylamino-1-ethyl-1,2,3,4-tetrahydro-quinolin-8-yl)-methanol

Guidance literature:: With sodium tetrahydroborate; In methanol; Yield given; Ambient temperature;
DOI:10.1248/cpb.38.1575

Reference yield:

: 5344-90-1
2-Aminobenzyl alcohol

: 130020-38-1
(4-Cyclohexylamino-1-ethyl-1,2,3,4-tetrahydro-quinolin-8-yl)-methanol

Guidance literature:: Multi-step reaction with 10 steps

1: 74 percent / Et₃N / tetrahydrofuran / 2 h / Ambient temperature

2: 90 percent / K₂CO₃ / dimethylformamide / 5 h / 50 °C

3: 92 percent / Na₂CO₃ / methanol / 8 h / Heating

4: 60 percent / polyphosphoric acid / 1 h / 120 °C

5: 72 percent / p-TsOH / toluene / 3 h / Heating

6: 61 percent / NaOH / methanol / 5 h / Heating

8: 98 percent / 10percent HCl / tetrahydrofuran / Ambient temperature

9: molecular sieves 3A, p-TsOH / methanol / 65 °C

10: NaBH₄ / methanol / Ambient temperature

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; PPA; 3 A molecular sieve; sodium carbonate; potassium carbonate; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1248/cpb.38.1575

Reference yield:

: 13213-88-2
1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one

: 130020-38-1
(4-Cyclohexylamino-1-ethyl-1,2,3,4-tetrahydro-quinolin-8-yl)-methanol

Guidance literature:: Multi-step reaction with 9 steps

1: 90 percent / K₂CO₃ / dimethylformamide / 5 h / 50 °C

2: 92 percent / Na₂CO₃ / methanol / 8 h / Heating

3: 60 percent / polyphosphoric acid / 1 h / 120 °C

4: 72 percent / p-TsOH / toluene / 3 h / Heating

5: 61 percent / NaOH / methanol / 5 h / Heating

7: 98 percent / 10percent HCl / tetrahydrofuran / Ambient temperature

8: molecular sieves 3A, p-TsOH / methanol / 65 °C

9: NaBH₄ / methanol / Ambient temperature

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; PPA; 3 A molecular sieve; sodium carbonate; potassium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1248/cpb.38.1575