trans-5S-(2'S-benzyloxycarbonylamino-3'phenylpropanamido)-7-(2-naphthylsulfonyl)hept-6-en-1-tert-butyloxycarbonylamine

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Chemical Name:trans-5S-(2'S-benzyloxycarbonylamino-3'phenylpropanamido)-7-(2-naphthylsulfonyl)hept-6-en-1-tert-butyloxycarbonylamine
CAS No.:1451454-08-2
Molecular Formula:C₃₉H₄₅N₃O₇S
Molecular Weight:699.868
Hs Code.:

Synonyms:

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Chemical Property of trans-5S-(2'S-benzyloxycarbonylamino-3'phenylpropanamido)-7-(2-naphthylsulfonyl)hept-6-en-1-tert-butyloxycarbonylamine

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Technology Process of trans-5S-(2'S-benzyloxycarbonylamino-3'phenylpropanamido)-7-(2-naphthylsulfonyl)hept-6-en-1-tert-butyloxycarbonylamine

There total 7 articles about trans-5S-(2'S-benzyloxycarbonylamino-3'phenylpropanamido)-7-(2-naphthylsulfonyl)hept-6-en-1-tert-butyloxycarbonylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1451454-53-7
2S-(2S-benzyloxycarbonylamino-3-phenylpropanamido)-6-(tert-butoxycarbonylamino)hexanal

: 183444-05-5
diethyl (naphthalen-2-ylsulfonyl)methylphosphonate

: 1451454-08-2
trans-5S-(2'S-benzyloxycarbonylamino-3'phenylpropanamido)-7-(2-naphthylsulfonyl)hept-6-en-1-tert-butyloxycarbonylamine

Guidance literature:: diethyl (naphthalen-2-ylsulfonyl)methylphosphonate; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.5h; Inert atmosphere;

2S-(2S-benzyloxycarbonylamino-3-phenylpropanamido)-6-(tert-butoxycarbonylamino)hexanal; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 16h; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/jm400294w

Reference yield:

: 42362-08-3
(S)-methyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-phenylpropanamido)-6-((tert-butoxycarbonyl)amino)hexanoate

: 1451454-08-2
trans-5S-(2'S-benzyloxycarbonylamino-3'phenylpropanamido)-7-(2-naphthylsulfonyl)hept-6-en-1-tert-butyloxycarbonylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate; lithium chloride / tetrahydrofuran; ethanol / 16 h / 20 °C

2.1: pyridinium chlorochromate / dichloromethane / 6 h / 20 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

3.2: 16 h / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; sodium hydride; pyridinium chlorochromate; lithium chloride; In tetrahydrofuran; ethanol; dichloromethane; mineral oil; 3.1: |Horner-Wadsworth-Emmons Olefination / 3.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1021/jm400294w

Reference yield:

: 1451453-87-4
2S-(2S-benzyloxycarbonylamino-3-phenylpropanamido)-6-(tert-butoxycarbonylamino)hexanol

: 1451454-08-2
trans-5S-(2'S-benzyloxycarbonylamino-3'phenylpropanamido)-7-(2-naphthylsulfonyl)hept-6-en-1-tert-butyloxycarbonylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridinium chlorochromate / dichloromethane / 6 h / 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

2.2: 16 h / 0 - 20 °C / Inert atmosphere

With sodium hydride; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; mineral oil; 2.1: |Horner-Wadsworth-Emmons Olefination / 2.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1021/jm400294w