2S-(2S-benzyloxycarbonylamino-3-phenylpropanamido)-6-(tert-butoxycarbonylamino)hexanal

Base Information

Chemical Name:2S-(2S-benzyloxycarbonylamino-3-phenylpropanamido)-6-(tert-butoxycarbonylamino)hexanal
CAS No.:1451454-53-7
Molecular Formula:C₂₈H₃₇N₃O₆
Molecular Weight:511.618
Hs Code.:

Synonyms:2S-(2S-benzyloxycarbonylamino-3-phenylpropanamido)-6-(tert-butoxycarbonylamino)hexanal

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Chemical Property of 2S-(2S-benzyloxycarbonylamino-3-phenylpropanamido)-6-(tert-butoxycarbonylamino)hexanal

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Technology Process of 2S-(2S-benzyloxycarbonylamino-3-phenylpropanamido)-6-(tert-butoxycarbonylamino)hexanal

There total 8 articles about 2S-(2S-benzyloxycarbonylamino-3-phenylpropanamido)-6-(tert-butoxycarbonylamino)hexanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: benzyl 1-{[6-tert-butoxycarbonylamino-1-(methoxy(methyl)amino)-1-oxohexan-2S-yl]amino-1-oxo-3-phenylpropan-2S-yl}carbamate

: 1451454-53-7
2S-(2S-benzyloxycarbonylamino-3-phenylpropanamido)-6-(tert-butoxycarbonylamino)hexanal

Guidance literature:: With potassium hydrogensulfate; lithium aluminium tetrahydride; In tetrahydrofuran; ethyl acetate; at -78 - 20 ℃; for 0.583333h; Inert atmosphere;
DOI:10.1039/c4ob01412j

Reference yield: 55.0%

: 1451453-87-4
2S-(2S-benzyloxycarbonylamino-3-phenylpropanamido)-6-(tert-butoxycarbonylamino)hexanol

: 1451454-53-7
2S-(2S-benzyloxycarbonylamino-3-phenylpropanamido)-6-(tert-butoxycarbonylamino)hexanal

Guidance literature:: With pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 6h;
DOI:10.1021/jm400294w

Reference yield:

: 71989-26-9
Fmoc-Lys(tert-butoxycarbonyl)

: 1451454-53-7
2S-(2S-benzyloxycarbonylamino-3-phenylpropanamido)-6-(tert-butoxycarbonylamino)hexanal

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / Inert atmosphere

1.2: 24 h / Inert atmosphere

2.1: piperidine / acetonitrile / 0.25 h

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

3.2: 24 h / 0 - 20 °C / Inert atmosphere

4.1: lithium aluminium tetrahydride; potassium hydrogensulfate / tetrahydrofuran; ethyl acetate / 0.58 h / -78 - 20 °C / Inert atmosphere

With piperidine; potassium hydrogensulfate; lithium aluminium tetrahydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1039/c4ob01412j