(1R,4S)-4,7,7-Trimethyl-3-oxo-2-oxa-bicyclo[2.2.1]heptane-1-carboxylic acid (1S,2R,3R,4S,5S,6R)-2,3,4,6-tetrakis-benzyloxy-5-hydroxy-cyclohexyl ester

Base Information

Chemical Name:(1R,4S)-4,7,7-Trimethyl-3-oxo-2-oxa-bicyclo[2.2.1]heptane-1-carboxylic acid (1S,2R,3R,4S,5S,6R)-2,3,4,6-tetrakis-benzyloxy-5-hydroxy-cyclohexyl ester
CAS No.:132662-61-4
Molecular Formula:C₄₄H₄₈O₉
Molecular Weight:720.86
Hs Code.:

(1R,4S)-4,7,7-Trimethyl-3-oxo-2-oxa-bicyclo[2.2.1]heptane-1-carboxylic acid (1S,2R,3R,4S,5S,6R)-2,3,4,6-tetrakis-benzyloxy-5-hydroxy-cyclohexyl ester

Synonyms:

Suppliers and Price of (1R,4S)-4,7,7-Trimethyl-3-oxo-2-oxa-bicyclo[2.2.1]heptane-1-carboxylic acid (1S,2R,3R,4S,5S,6R)-2,3,4,6-tetrakis-benzyloxy-5-hydroxy-cyclohexyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,4S)-4,7,7-Trimethyl-3-oxo-2-oxa-bicyclo[2.2.1]heptane-1-carboxylic acid (1S,2R,3R,4S,5S,6R)-2,3,4,6-tetrakis-benzyloxy-5-hydroxy-cyclohexyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,4S)-4,7,7-Trimethyl-3-oxo-2-oxa-bicyclo[2.2.1]heptane-1-carboxylic acid (1S,2R,3R,4S,5S,6R)-2,3,4,6-tetrakis-benzyloxy-5-hydroxy-cyclohexyl ester

There total 14 articles about (1R,4S)-4,7,7-Trimethyl-3-oxo-2-oxa-bicyclo[2.2.1]heptane-1-carboxylic acid (1S,2R,3R,4S,5S,6R)-2,3,4,6-tetrakis-benzyloxy-5-hydroxy-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 39637-74-6,104530-16-7
(-)-camphanic acid chloride

: 131147-14-3,131233-76-6,132746-98-6,132747-00-3,141040-63-3,145553-67-9
1,2,4,6-tetra-O-benzyl-DL-myo-inositol

: 132662-61-4,132746-99-7
(1R,4S)-4,7,7-Trimethyl-3-oxo-2-oxa-bicyclo[2.2.1]heptane-1-carboxylic acid (1R,2S,3S,4R,5R,6S)-2,3,4,6-tetrakis-benzyloxy-5-hydroxy-cyclohexyl ester

: 132662-61-4,132746-99-7
(1R,4S)-4,7,7-Trimethyl-3-oxo-2-oxa-bicyclo[2.2.1]heptane-1-carboxylic acid (1S,2R,3R,4S,5S,6R)-2,3,4,6-tetrakis-benzyloxy-5-hydroxy-cyclohexyl ester

Guidance literature:: DOI:10.1016/S0040-4039(00)97206-X

Reference yield: 47.0%

: 39637-74-6,104530-16-7
(-)-camphanic acid chloride

: 131147-14-3,131233-76-6,132746-98-6,132747-00-3,141040-63-3,145553-67-9
1,2,4,6-tetra-O-benzyl-DL-myo-inositol

: 132662-61-4,132746-99-7
(1R,4S)-4,7,7-Trimethyl-3-oxo-2-oxa-bicyclo[2.2.1]heptane-1-carboxylic acid (1R,2S,3S,4R,5R,6S)-2,3,4,6-tetrakis-benzyloxy-5-hydroxy-cyclohexyl ester

: 132662-61-4,132746-99-7
(1R,4S)-4,7,7-Trimethyl-3-oxo-2-oxa-bicyclo[2.2.1]heptane-1-carboxylic acid (1S,2R,3R,4S,5S,6R)-2,3,4,6-tetrakis-benzyloxy-5-hydroxy-cyclohexyl ester

Guidance literature:: DOI:10.1016/S0040-4039(00)97206-X

Reference yield:

: 100-39-0
benzyl bromide

: 132662-61-4,132746-99-7
(1R,4S)-4,7,7-Trimethyl-3-oxo-2-oxa-bicyclo[2.2.1]heptane-1-carboxylic acid (1R,2S,3S,4R,5R,6S)-2,3,4,6-tetrakis-benzyloxy-5-hydroxy-cyclohexyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: NaH / dimethylformamide

2: 1) CF₃COOH, H₂O (9:1), 2) NH₃ / 1) 40 deg C, 0.5 h, 2) MeOH, H₂O, 4 h

3: 71 percent / 5percent NaOH, Bu₄N⁺I^- / CH₂Cl₂ / 16 h / 45 °C

4: 44 percent / pyridine / 0 °C

With sodium hydroxide; ammonia; water; tetra-(n-butyl)ammonium iodide; sodium hydride; trifluoroacetic acid; In pyridine; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)97206-X