3-[1-Hydroxy-3-(2-iodo-phenyl)-propyl]-3H-isobenzofuran-1-one

Base Information

Chemical Name:3-[1-Hydroxy-3-(2-iodo-phenyl)-propyl]-3H-isobenzofuran-1-one
CAS No.:111373-33-2
Molecular Formula:C₁₇H₁₅IO₃
Molecular Weight:394.209
Hs Code.:

Synonyms:

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Chemical Property of 3-[1-Hydroxy-3-(2-iodo-phenyl)-propyl]-3H-isobenzofuran-1-one

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Technology Process of 3-[1-Hydroxy-3-(2-iodo-phenyl)-propyl]-3H-isobenzofuran-1-one

There total 7 articles about 3-[1-Hydroxy-3-(2-iodo-phenyl)-propyl]-3H-isobenzofuran-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 88-67-5
2-Iodobenzoic acid

: 111373-33-2,111373-36-5
3-[1-Hydroxy-3-(2-iodo-phenyl)-propyl]-3H-isobenzofuran-1-one

Guidance literature:: Multi-step reaction with 7 steps

1: 99 percent / BH₃SMe₂ / tetrahydrofuran / 12 h / Ambient temperature

2: 91 percent / tetrahydrofuran / 5 h / 0 deg C to reflux

3: 97 percent / dimethylformamide; tetrahydrofuran / 6 h / 0 deg C to room temperature

4: 95 percent / NaCl, H₂O / dimethylsulfoxide / 15 h / 180 °C

5: 73 percent / i-Bu₂AlH / tetrahydrofuran / 2 h / -50 deg C to -30 deg C

6: 81 percent / PCC, Celite, Molecular Sieves / CH₂Cl₂ / 1 h / Ambient temperature

7: 1.) LDA / 1.) THF, -50 deg C, 30 min 2.) -78 deg C, 5 min

With molecular sieve; dimethylsulfide borane complex; Celite; water; diisobutylaluminium hydride; pyridinium chlorochromate; sodium chloride; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)95678-8

Reference yield:

: 5159-41-1
2-iodobenzyl alcohol

: 111373-33-2,111373-36-5
3-[1-Hydroxy-3-(2-iodo-phenyl)-propyl]-3H-isobenzofuran-1-one

Guidance literature:: Multi-step reaction with 6 steps

1: 91 percent / tetrahydrofuran / 5 h / 0 deg C to reflux

2: 97 percent / dimethylformamide; tetrahydrofuran / 6 h / 0 deg C to room temperature

3: 95 percent / NaCl, H₂O / dimethylsulfoxide / 15 h / 180 °C

4: 73 percent / i-Bu₂AlH / tetrahydrofuran / 2 h / -50 deg C to -30 deg C

5: 81 percent / PCC, Celite, Molecular Sieves / CH₂Cl₂ / 1 h / Ambient temperature

6: 1.) LDA / 1.) THF, -50 deg C, 30 min 2.) -78 deg C, 5 min

With molecular sieve; Celite; water; diisobutylaluminium hydride; pyridinium chlorochromate; sodium chloride; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)95678-8

Reference yield:

: 26059-41-6
3-(2-iodophenyl)-1-propanol

: 111373-33-2,111373-36-5
3-[1-Hydroxy-3-(2-iodo-phenyl)-propyl]-3H-isobenzofuran-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / PCC, Celite, Molecular Sieves / CH₂Cl₂ / 1 h / Ambient temperature

2: 1.) LDA / 1.) THF, -50 deg C, 30 min 2.) -78 deg C, 5 min

With molecular sieve; Celite; pyridinium chlorochromate; lithium diisopropyl amide; In dichloromethane;
DOI:10.1016/S0040-4039(00)95678-8