Technology Process of (2aS,3R,8aR,8bS)-6,8b-Dimethyl-7-oxo-3-phenylsulfanyl-2a,3,4,5,7,8,8a,8b-octahydro-2H-naphtho[1,8-bc]furan-3-carboxylic acid methyl ester
There total 8 articles about (2aS,3R,8aR,8bS)-6,8b-Dimethyl-7-oxo-3-phenylsulfanyl-2a,3,4,5,7,8,8a,8b-octahydro-2H-naphtho[1,8-bc]furan-3-carboxylic acid methyl ester which
guide to synthetic route it.
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synthetic route:
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106814-22-6
(2aS,3R,8aR,8bS)-6,8b-Dimethyl-7-oxo-3-phenylsulfanyl-2a,3,4,5,7,8,8a,8b-octahydro-2H-naphtho[1,8-bc]furan-3-carboxylic acid methyl ester
- Guidance literature:
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Multi-step reaction with 8 steps
1: 1.) LDA / 1.) THF, -78 deg C, 2.) THF, -95 deg C
2: 70 percent / tetrahydrofuran / 0.5 h / 0 °C
3: HClO4 / tetrahydrofuran / 0.5 h / 0 °C
4: NaOCH3 / methanol / 1 h / 25 °C
5: 1.) LDA / 1.) THF, -78 deg C
6: palladium acetate
7: NaOEt, H2O / ethanol
With
perchloric acid; water; sodium methylate; sodium ethanolate; palladium diacetate; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; ethanol;
DOI:10.1016/S0040-4039(00)84455-X
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106814-22-6
(2aS,3R,8aR,8bS)-6,8b-Dimethyl-7-oxo-3-phenylsulfanyl-2a,3,4,5,7,8,8a,8b-octahydro-2H-naphtho[1,8-bc]furan-3-carboxylic acid methyl ester
- Guidance literature:
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Multi-step reaction with 5 steps
1: NaOCH3 / methanol / 1 h / 25 °C
2: 1.) LDA / 1.) THF, -78 deg C
3: palladium acetate
4: NaOEt, H2O / ethanol
With
water; sodium methylate; sodium ethanolate; palladium diacetate; lithium diisopropyl amide;
In
methanol; ethanol;
DOI:10.1016/S0040-4039(00)84455-X
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106814-22-6
(2aS,3R,8aR,8bS)-6,8b-Dimethyl-7-oxo-3-phenylsulfanyl-2a,3,4,5,7,8,8a,8b-octahydro-2H-naphtho[1,8-bc]furan-3-carboxylic acid methyl ester
- Guidance literature:
-
Multi-step reaction with 2 steps
1: NaOEt, H2O / ethanol
With
water; sodium ethanolate;
In
ethanol;
DOI:10.1016/S0040-4039(00)84455-X