42435-82-5

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
3-(Phenylthio)-2(5H)-furanone is utilized as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its unique structure allows it to be a versatile building block for the development of new drugs and agricultural products, enhancing their efficacy and performance.
Used in Fragrance and Flavoring Agent Production:
3-(Phenylthio)-2(5H)-furanone is employed as a fragrance and flavoring agent due to its distinct odor. It contributes to the creation of a wide range of scents and tastes in products such as perfumes, colognes, and food items, adding depth and complexity to their sensory profiles.
Used in Pesticide Manufacturing:
3-(Phenylthio)-2(5H)-furanone is used in the manufacturing of pesticides, where its antimicrobial and antifungal properties help protect crops and enhance agricultural yields. Its incorporation into these products ensures effective pest control while maintaining the quality and safety of the produce.
Used in Industrial Chemical Production:
Beyond its applications in pharmaceuticals, agrochemicals, fragrances, and pesticides, 3-(Phenylthio)-2(5H)-furanone is also used in the production of other industrial chemicals. Its versatility and chemical properties make it a valuable component in various chemical processes and formulations.

InChI:InChI=1/C10H8O2S/c11-10-9(6-7-12-10)13-8-4-2-1-3-5-8/h1-6H,7H2

Upstream product

• 54144-98-8 α-phenylsulfinyl-γ-butyrolactone 
• 15286-68-7 trans-3-(phenylthio)prop-2-en-1-ol 
• 62675-47-2 α-chloro-α-(phenylthio)-γ-butyrolactone 
• 35998-30-2 3-(phenylsulfanyl)-3,4-dihydrofuran-2-one 
• 930-69-8 sodium thiophenolate 
• 27098-65-3 3-phenylsulfanyl-propionaldehyde 
• 108-98-5 thiophenol 
• 2973-86-6 lithium thiophenoxide 

Downstream Products

• 95412-14-9 3-(4-Nitro-phenyl)-5H-furan-2-one 
• 57200-23-4 3-phenyl-2(5H)-furanone 
• 143392-20-5 3-(2-methylphenyl)-2,5-dihydrofuran-2-one 
• 145439-11-8 3-(3-Trifluoromethylphenyl)furan-2(5H)-one 
• 145439-10-7 3-(2-Methoxycarbonylphenyl)furan-2(5H)-one 
• 144602-80-2 3-phenylthio-4-(1'-dimethylphenylsilylmethylethenyl)dihydro-2(3H)-furanone 
• 126393-68-8 5-Methoxy-4-methyl-7a-phenylsulfanyl-3a,7a-dihydro-3H,4H-isobenzofuran-1,7-dione 
• 57061-31-1 3-benzenesulfinyl-5H-furan-2-one 
• 106814-19-1 (3R,4S)-4-((S)-1,3-Dimethyl-4-oxo-2-vinyl-cyclohex-2-enyl)-3-phenylsulfanyl-dihydro-furan-2-one 
• 106814-23-7 (3aS,9aR,9bR)-6,9a-Dimethyl-3a-phenylsulfanyl-4,5,9a,9b-tetrahydro-1H,3aH-naphtho[1,2-c]furan-3,7-dione 
• 106814-21-5 (1R,2S,6R,7R,8S)-2,6-Dimethyl-3-oxo-8-phenylsulfanyl-11-oxa-tricyclo[5.3.2.0^1,6]dodecane-8-carboxylic acid methyl ester 
• 106814-24-8 (3S,4R)-4-((R)-2-Hydroxy-4-methoxy-1,3-dimethyl-2-vinyl-cyclohex-3-enyl)-3-phenylsulfanyl-dihydro-furan-2-one 
• 106814-22-6 (2aS,3R,8aR,8bS)-6,8b-Dimethyl-7-oxo-3-phenylsulfanyl-2a,3,4,5,7,8,8a,8b-octahydro-2H-naphtho[1,8-bc]furan-3-carboxylic acid methyl ester 
• 106814-25-9 (3aS,9aR,9bR)-6,9a-Dimethyl-3a-phenylsulfanyl-7-trimethylsilanyloxy-3a,4,5,9,9a,9b-hexahydro-1H-naphtho[1,2-c]furan-3-one 

Relevant academic research and scientific papers

Method for synthesizing 4-vinyl-2(5H)-furanone

The invention discloses a method for synthesizing 4-vinyl-2(5H)-furanone. The method comprises the following steps: step (1) taking and adding metal sodium into methanol, dripping thiophenol into themethanol, and then continuously adding alpha-bromo-gamma

Enantioselective direct vinylogous michael addition of functionalized furanones to nitroalkenes catalyzed by an axially chiral guanidine base

The highly syn-diastereo- and enantioselective direct vinylogous Michael addition ofα-thio substituted furanones with conjugate nitroalkenes was demonstrated using an axially chiral guanidine base catalyst. The method provides facile access to enantioenriched α,γ-functionalized butenolides that can be further manipulated, thereby rendering them useful synthetic intermediates. 2011 American Chemical Society.

Preparation and palladium-catalysed cross-coupling reactions of 3-and 4-tributylstannylfuran-2(5H)-ones

Stannylfuranones 1 and 2 were prepared by ipso radical desulfurative stannylation of phenylsulfanylfuranones 3 and 16. Compounds 1 and 2 underwent Stille coupling reactions with aryl iodides to give 3- and 4-arylfuran-2(5H)-ones.

PUMMERER REARRANGEMENT PROMOTED BY POLYPHOSPHORIC ACID TRIMETHYLSILYL ESTER (PPSE)

It was found that PPSE catalyzed Pummerer rearrangement of various types of sulfoxides.When α-(phenylsulfinyl)acetophenone was used as sulfoxide, unusual product, phenyl phenylthioglyoxylate was isolated.The reaction seems to proceed via phosphorylation of oxygen of sulfoxides.