(+)-trans-1-acetoxy-2-nitroxycyclohexane

Base Information

• Chemical Name: (+)-trans-1-acetoxy-2-nitroxycyclohexane
• CAS No.: 175416-74-7
• Molecular Formula: C₈H₁₃NO₅
• Molecular Weight: 203.195
• Mol file: 175416-74-7.mol

Synonyms:

Chemical Property of (+)-trans-1-acetoxy-2-nitroxycyclohexane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)-trans-1-acetoxy-2-nitroxycyclohexane

There total 4 articles about (+)-trans-1-acetoxy-2-nitroxycyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

trans-1-acetoxy-2-nitroxycyclohexane → (1R,2R)-2-nitroxycyclohexan-1-ol (175416-72-5) + (+)-trans-1-acetoxy-2-nitroxycyclohexane (175416-74-7)

Guidance literature:

With phosphate buffer (0.5M, pH=8.0); In diethyl ether; for 72h; Yields of byproduct given; pig liver acetone powder (PLAP);

DOI:10.1016/0957-4166(95)00409-2

Reference yield:

trans-(1S(R),2S(R))-2-hydroxycyclohexyl nitrate (32342-26-0,32342-27-1,75561-13-6) → (+)-trans-1-acetoxy-2-nitroxycyclohexane (175416-74-7)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / CH₂Cl₂

2: phosphate buffer (0.5M, pH=8.0) / diethyl ether / 72 h / pig liver acetone powder (PLAP)

With pyridine; phosphate buffer (0.5M, pH=8.0); In diethyl ether; dichloromethane;

DOI:10.1016/0957-4166(95)00409-2

Reference yield:

cyclohexane-1,2-epoxide (286-20-4) → (+)-trans-1-acetoxy-2-nitroxycyclohexane (175416-74-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 67 percent / ammonium cerium(IV) nitrate / 2-methyl-propan-2-ol / 2.5 h / Ambient temperature

2: pyridine / CH₂Cl₂

3: phosphate buffer (0.5M, pH=8.0) / diethyl ether / 72 h / pig liver acetone powder (PLAP)

With pyridine; ammonium cerium(IV) nitrate; phosphate buffer (0.5M, pH=8.0); In diethyl ether; dichloromethane; tert-butyl alcohol;

DOI:10.1016/0957-4166(95)00409-2

upstream raw materials:

trans-(1S(R),2S(R))-2-hydroxycyclohexyl nitrate

cyclohexane-1,2-epoxide