Technology Process of Pyrido[2,3-c]pyridazine-3-carboxylic acid,
7-chloro-6-fluoro-1,4-dihydro-4-oxo-, ethyl ester
There total 8 articles about Pyrido[2,3-c]pyridazine-3-carboxylic acid,
7-chloro-6-fluoro-1,4-dihydro-4-oxo-, ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tributylphosphine;
In
di-isopropyl ether;
for 18h;
Ambient temperature;
DOI:10.1248/cpb.38.3211
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 81 percent / SOCl2 / 1 h / Heating
2: 1.) Mg, CCl4, EtOH / 1.) Et2O, reflux, 30 min, 2.) 10 min
3: p-toluenesulfonic acid / H2O / 2 h / Heating
4: 88 percent / p-toluenesulfonyl azide, Et3N / acetonitrile / 1 h / Ambient temperature
5: 21 percent / tri-n-butylphosphine / diisopropyl ether / 18 h / Ambient temperature
With
tetrachloromethane; thionyl chloride; 4-toluenesulfonyl azide; ethanol; tributylphosphine; toluene-4-sulfonic acid; magnesium; triethylamine;
In
di-isopropyl ether; water; acetonitrile;
DOI:10.1248/cpb.38.3211
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 88 percent / p-toluenesulfonyl azide, Et3N / acetonitrile / 1 h / Ambient temperature
2: 21 percent / tri-n-butylphosphine / diisopropyl ether / 18 h / Ambient temperature
With
4-toluenesulfonyl azide; tributylphosphine; triethylamine;
In
di-isopropyl ether; acetonitrile;
DOI:10.1248/cpb.38.3211
