Technology Process of (2R)-2-(2,2-dimethyl(4H-benzo[3,4-e]1,3-dioxin-6-yl))-N-(tert-butyl)-2-perhydro-2H-pyran-2-yloxyacetamide
There total 5 articles about (2R)-2-(2,2-dimethyl(4H-benzo[3,4-e]1,3-dioxin-6-yl))-N-(tert-butyl)-2-perhydro-2H-pyran-2-yloxyacetamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
silver trifluoroacetate;
In
acetonitrile;
at 40 ℃;
for 96h;
DOI:10.1021/jo026410i
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 88 percent / TsOH / CH2Cl2 / 4 h / 20 °C
2.1: trifluoroacetic anhydride; pyridine / CH2Cl2; tetrahydrofuran / 0.25 h / 0 °C
2.2: LiOH*H2O / CH2Cl2; tetrahydrofuran; H2O / 3 h / 0 - 20 °C
3.1: 57 percent / AgOCOCF3 / acetonitrile / 96 h / 40 °C
With
pyridine; silver trifluoroacetate; toluene-4-sulfonic acid; trifluoroacetic anhydride;
In
tetrahydrofuran; dichloromethane; acetonitrile;
2.1: Pummerer reaction;
DOI:10.1021/jo026410i
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 89 percent / NaHMDS / pyridine; tetrahydrofuran / 2 h / 0 °C
2.1: 88 percent / TsOH / CH2Cl2 / 4 h / 20 °C
3.1: trifluoroacetic anhydride; pyridine / CH2Cl2; tetrahydrofuran / 0.25 h / 0 °C
3.2: LiOH*H2O / CH2Cl2; tetrahydrofuran; H2O / 3 h / 0 - 20 °C
4.1: 57 percent / AgOCOCF3 / acetonitrile / 96 h / 40 °C
With
pyridine; sodium hexamethyldisilazane; silver trifluoroacetate; toluene-4-sulfonic acid; trifluoroacetic anhydride;
In
tetrahydrofuran; pyridine; dichloromethane; acetonitrile;
3.1: Pummerer reaction;
DOI:10.1021/jo026410i
