4-phenyl-N-pyridin-4-ylbenzamide

Base Information

• Chemical Name: 4-phenyl-N-pyridin-4-ylbenzamide
• CAS No.: 304882-40-4
• Molecular Formula: C₁₈H₁₄N₂O
• Molecular Weight: 274.322
• DSSTox Substance ID: DTXSID401267047
• Nikkaji Number: J3.463.299E
• ChEMBL ID: CHEMBL1478316
• Mol file: 304882-40-4.mol

Synonyms:4-phenyl-N-pyridin-4-ylbenzamide;304882-40-4;N-(pyridin-4-yl)-[1,1'-biphenyl]-4-carboxamide;MLS000717999;SMR000279567;N-(4-pyridinyl)[1,1'-biphenyl]-4-carboxamide;Oprea1_459721;Oprea1_613596;cid_765802;CHEMBL1478316;BDBM46408;4-phenyl-N-(4-pyridyl)benzamide;DTXSID401267047;HMS2669I08;4-Phenyl-N-(4-pyridinyl)benzamide;4-phenyl-N-pyridin-4-yl-benzamide;STK085926;AKOS000603715;N-(pyridin-4-yl)biphenyl-4-carboxamide;NCGC00301864-01;CS-0333218;N-4-Pyridinyl[1,1'-biphenyl]-4-carboxamide;N-pyridin-4-yl-1,1'-biphenyl-4-carboxamide;AB00614253-06;AA-504/32991041;SR-01000393843;11T-0621;SR-01000393843-1

Chemical Property of 4-phenyl-N-pyridin-4-ylbenzamide

Chemical Property:

• XLogP3: 3.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 274.110613074
• Heavy Atom Count: 21
• Complexity: 324

Purity/Quality:

99% ^*data from raw suppliers

N-(4-PYRIDINYL)[1,1'-BIPHENYL]-4-CARBOXAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)NC3=CC=NC=C3

Technology Process of 4-phenyl-N-pyridin-4-ylbenzamide

There total 1 articles about 4-phenyl-N-pyridin-4-ylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

4-aminopyridine (504-24-5) + biphenyl-4-carboxylic acid (92-92-2) → N-(pyridin-4-yl)-[1,1'-biphenyl]-4-carboxamide (304882-40-4)

Guidance literature:

biphenyl-4-carboxylic acid; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;

4-aminopyridine; In dichloromethane; for 1h; Inert atmosphere;

DOI:10.1016/j.ejmech.2020.112761

Reference yield: 94.0%

N-(pyridin-4-yl)-[1,1'-biphenyl]-4-carboxamide (304882-40-4) + benzyl bromide (100-39-0) → 4-([1,1'-biphenyl]-4-ylcarboxamido)-1-benzylpyridin-1-ium bromide

Guidance literature:

In acetonitrile; at 80 ℃; for 1h;

DOI:10.1016/j.ejmech.2020.112761

upstream raw materials:

4-aminopyridine

biphenyl-4-carboxylic acid