Technology Process of 2,6-Di-O-benzyl-3,4-O-isopropylidene-β-D-galactopyranosyl-(1->4)-<(2,3,4-tri-O-benzyl-α-L-fucopyranosyl)-(1->3)>-2-azido-6-O-benzyl-2-desoxy-β-D-glucopyranoside
There total 8 articles about 2,6-Di-O-benzyl-3,4-O-isopropylidene-β-D-galactopyranosyl-(1->4)-<(2,3,4-tri-O-benzyl-α-L-fucopyranosyl)-(1->3)>-2-azido-6-O-benzyl-2-desoxy-β-D-glucopyranoside which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 83 percent / sodium hydride / dimethylformamide / 5 h / 0 °C
2: 1) H2, 2) mercury(II) oxide, mercury(II) chloride / 1) (1,5-cyclooctadiene)bis-(methyldiphenylphosphine)iridium hexafluorophosphate / 1) THF, 3-4 h, 2) acetone/water, 1 h
3: 89 percent / ZnCl2*Et2O / CH2Cl2 / 0.5 h
4: tetrabutylammonium fluoride / CH2Cl2; tetrahydrofuran / 6 h / -15 °C
With
tetrabutyl ammonium fluoride; hydrogen; sodium hydride; mercury dichloride; mercury(II) oxide;
zinc chloride diethyl ether; (1,5-cyclooctadiene)[bis(methyldiphenylphosphine)]iridium(I) hexafluorophosphate;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 89 percent / ZnCl2*Et2O / CH2Cl2 / 0.5 h
2: tetrabutylammonium fluoride / CH2Cl2; tetrahydrofuran / 6 h / -15 °C
With
tetrabutyl ammonium fluoride;
zinc chloride diethyl ether;
In
tetrahydrofuran; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 68 percent / NaH / dimethylformamide / 72 h / -10 °C
2: 92 percent / iron(III) chloride / 0.5 h / Heating
3: 83 percent / sodium hydride / dimethylformamide / 5 h / 0 °C
4: 1) H2, 2) mercury(II) oxide, mercury(II) chloride / 1) (1,5-cyclooctadiene)bis-(methyldiphenylphosphine)iridium hexafluorophosphate / 1) THF, 3-4 h, 2) acetone/water, 1 h
5: 89 percent / ZnCl2*Et2O / CH2Cl2 / 0.5 h
6: tetrabutylammonium fluoride / CH2Cl2; tetrahydrofuran / 6 h / -15 °C
With
tetrabutyl ammonium fluoride; hydrogen; iron(III) chloride; sodium hydride; mercury dichloride; mercury(II) oxide;
zinc chloride diethyl ether; (1,5-cyclooctadiene)[bis(methyldiphenylphosphine)]iridium(I) hexafluorophosphate;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
