tert-butyl N-[3-[[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-(3-fluoro-4-methylbenzoyl)amino]propyl]carbamate

Base Information

Chemical Name:tert-butyl N-[3-[[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-(3-fluoro-4-methylbenzoyl)amino]propyl]carbamate
CAS No.:876191-41-2
Molecular Formula:C₃₃H₄₀FN₅O₄S
Molecular Weight:621.776
Hs Code.:

tert-butyl N-[3-[[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-(3-fluoro-4-methylbenzoyl)amino]propyl]carbamate

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Chemical Property of tert-butyl N-[3-[[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-(3-fluoro-4-methylbenzoyl)amino]propyl]carbamate

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Technology Process of tert-butyl N-[3-[[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-(3-fluoro-4-methylbenzoyl)amino]propyl]carbamate

There total 13 articles about tert-butyl N-[3-[[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-(3-fluoro-4-methylbenzoyl)amino]propyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 162702-04-7
N-(4-cyano-3-methyl-1,2-thiazol-5-yl)-3-methylbutanamide

: 876191-41-2,876308-44-0
tert-butyl N-[3-[[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-(3-fluoro-4-methylbenzoyl)amino]propyl]carbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: ammonium hydroxide; dihydrogen peroxide / water / 16 h / 60 °C

2.1: ammonium hydroxide / 5 h / 140 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 25 °C

4.1: bromine; sodium acetate; acetic acid / 0.83 h / 100 °C

5.1: sodium azide / N,N-dimethyl-formamide / 1 h / 25 °C

6.1: 5%-palladium/activated carbon; hydrogen / methanol / 25 °C

7.1: dichloromethane / 3 h / 25 °C / Molecular sieve

7.2: 16 h / 25 °C / Molecular sieve

8.1: pyridine / 48 h / 25 °C

With pyridine; ammonium hydroxide; sodium azide; 5%-palladium/activated carbon; hydrogen; dihydrogen peroxide; bromine; sodium acetate; potassium carbonate; acetic acid; In methanol; dichloromethane; water; N,N-dimethyl-formamide; 6.1: Staudinger reaction;
DOI:10.1021/jm200629m

Reference yield:

: 162702-36-5
3-methyl-5-(3-methylbutanoylamino)-1,2-thiazole-4-carboxamide

: 876191-41-2,876308-44-0
tert-butyl N-[3-[[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-(3-fluoro-4-methylbenzoyl)amino]propyl]carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: ammonium hydroxide / 5 h / 140 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 25 °C

3.1: bromine; sodium acetate; acetic acid / 0.83 h / 100 °C

4.1: sodium azide / N,N-dimethyl-formamide / 1 h / 25 °C

5.1: 5%-palladium/activated carbon; hydrogen / methanol / 25 °C

6.1: dichloromethane / 3 h / 25 °C / Molecular sieve

6.2: 16 h / 25 °C / Molecular sieve

7.1: pyridine / 48 h / 25 °C

With pyridine; ammonium hydroxide; sodium azide; 5%-palladium/activated carbon; hydrogen; bromine; sodium acetate; potassium carbonate; acetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide; 5.1: Staudinger reaction;
DOI:10.1021/jm200629m

Reference yield:

: 758722-00-8
3-methyl-6-(2-methylpropyl)-5H-[1,2]thiazolo[4,5-e]pyrimidin-4-one

: 876191-41-2,876308-44-0
tert-butyl N-[3-[[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-(3-fluoro-4-methylbenzoyl)amino]propyl]carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 25 °C

2.1: bromine; sodium acetate; acetic acid / 0.83 h / 100 °C

3.1: sodium azide / N,N-dimethyl-formamide / 1 h / 25 °C

4.1: 5%-palladium/activated carbon; hydrogen / methanol / 25 °C

5.1: dichloromethane / 3 h / 25 °C / Molecular sieve

5.2: 16 h / 25 °C / Molecular sieve

6.1: pyridine / 48 h / 25 °C

With pyridine; sodium azide; 5%-palladium/activated carbon; hydrogen; bromine; sodium acetate; potassium carbonate; acetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide; 4.1: Staudinger reaction;
DOI:10.1021/jm200629m